Two-pore channels: going with the flows.
Biochem Soc Trans
; 50(4): 1143-1155, 2022 08 31.
Article
em En
| MEDLINE
| ID: mdl-35959977
ABSTRACT
In recent years, our understanding of the structure, mechanisms and functions of the endo-lysosomal TPC (two-pore channel) family have grown apace. Gated by the second messengers, NAADP and PI(3,5)P2, TPCs are an integral part of fundamental signal-transduction pathways, but their array and plasticity of cation conductances (Na+, Ca2+, H+) allow them to variously signal electrically, osmotically or chemically. Their relative tissue- and organelle-selective distribution, together with agonist-selective ion permeabilities provides a rich palette from which extracellular stimuli can choose. TPCs are emerging as mediators of immunity, cancer, metabolism, viral infectivity and neurodegeneration as this short review attests.
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MEDLINE
Assunto principal:
Canais de Cálcio
/
Cálcio
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article