Transformation from polycythemia vera to acute promyelocytic leukemia: Case report and literature review.
Medicine (Baltimore)
; 101(32): e30064, 2022 Aug 12.
Article
em En
| MEDLINE
| ID: mdl-35960050
ABSTRACT
INTRODUCTION:
Transformation from chronic myeloproliferative neoplasm to acute leukemia is a feature of myeloproliferative neoplasm; however, the rate is not high. Transformation to acute promyelocytic leukemia is rare. Here, we report a case of transformation of polycythemia vera to acute promyelocytic leukemia and describe a process of clonal evolution that has not yet been reported. PATIENT CONCERNS In this case, a 51-year-old woman was diagnosed with polycythemia vera and concomitant JAK2/V617F mutations in July 2019. She underwent intermittent phlebotomy and oral hydroxyurea irregularly. After 2 years, the patient complained of fatigue and poor sleep quality for 2 months. DIAGNOSIS Further examination revealed marked hypercellularity and grade 1 bone marrow fibrosis with the PML/RARαV variant (23.85% mutation load), WT1-Exon1 (37.8%), WT1-Exon9 (4.1%), JAK3-Exon7 (49.3%), and RELN-Exon55 (45.8%). According to the World Health Organization classification of tumors of hematopoietic and lymphoid tissues, the patient was ultimately diagnosed with a rare transformation of polycythemia vera to acute promyelocytic leukemia.INTERVENTIONS:
The patient underwent dual induction therapy with all-trans-retinoic acid and arsenic trioxide.OUTCOMES:
After 28 days of induction therapy, the patient achieved complete remission, was compliant and the treatment was well tolerated.CONCLUSION:
Polycythemia vera can transform into acute promyelocytic leukemia; therefore, it is important to review bone aspiration and other tests to perform a comprehensive assessment and monitor the disease status, to detect disease progression and intervene early when it transforms into acute promyelocytic leukemia.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Policitemia Vera
/
Leucemia Promielocítica Aguda
/
Mielofibrose Primária
/
Transtornos Mieloproliferativos
Tipo de estudo:
Diagnostic_studies
Limite:
Female
/
Humans
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Middle aged
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article