Farnesyl diphosphate synthase regulated endothelial proliferation and autophagy during rat pulmonary arterial hypertension induced by monocrotaline.

Jin, Tingting; Lu, Jiangting; Lv, Qingbo; Gong, Yingchao; Feng, Zhaojin; Ying, Hangying; Wang, Meihui; Fu, Guosheng; Jiang, Dongmei

Jin, Tingting; Lu, Jiangting; Lv, Qingbo; Gong, Yingchao; Feng, Zhaojin; Ying, Hangying; Wang, Meihui; Fu, Guosheng; Jiang, Dongmei.

Afiliação

Jin T; Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 3 East Qingchun Road, Hangzhou, 310016, Zhejiang, People's Republic of China.
Lu J; Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Hangzhou, China.
Lv Q; Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 3 East Qingchun Road, Hangzhou, 310016, Zhejiang, People's Republic of China.
Gong Y; Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Hangzhou, China.
Feng Z; Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 3 East Qingchun Road, Hangzhou, 310016, Zhejiang, People's Republic of China.
Ying H; Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Hangzhou, China.
Wang M; Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 3 East Qingchun Road, Hangzhou, 310016, Zhejiang, People's Republic of China.
Fu G; Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Hangzhou, China.
Jiang D; Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 3 East Qingchun Road, Hangzhou, 310016, Zhejiang, People's Republic of China.

Mol Med ; 28(1): 94, 2022 08 12.

Article em En | MEDLINE | ID: mdl-35962329

Assuntos

Hipertensão Pulmonar; Proteínas Monoméricas de Ligação ao GTP; Hipertensão Arterial Pulmonar; Animais; Autofagia; Proliferação de Células; Células Endoteliais/metabolismo; Geraniltranstransferase/metabolismo; Geraniltranstransferase/farmacologia; Hipertensão Pulmonar/tratamento farmacológico; Hipertensão Pulmonar/metabolismo; Ácido Mevalônico/farmacologia; Ácido Mevalônico/uso terapêutico; Monocrotalina/efeitos adversos; Proteínas Monoméricas de Ligação ao GTP/metabolismo; Proteínas Monoméricas de Ligação ao GTP/farmacologia; Proteínas Monoméricas de Ligação ao GTP/uso terapêutico; Fosfatidilinositol 3-Quinases/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Artéria Pulmonar; Ratos; Ratos Sprague-Dawley; Serina-Treonina Quinases TOR/metabolismo

Palavras-chave

Autophagy; Endothelial; Farnesyl diphosphate synthase; Proliferation; Pulmonary artery hypertension; Ras-related C3 botulinum toxin substrate 1

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Monoméricas de Ligação ao GTP / Hipertensão Arterial Pulmonar / Hipertensão Pulmonar Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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