Consumption of soy isoflavones during the prepubertal phase delays puberty and causes hypergonadotropic hypogonadism with disruption of hypothalamic-pituitary gonadotropins regulation in male rats.

Oliveira, Jeane Maria; Oliveira, Isabela Medeiros; Sleiman, Hanan Khaled; Dal Forno, Gonzalo Ogliari; Romano, Marco Aurelio; Romano, Renata Marino

Oliveira, Jeane Maria; Oliveira, Isabela Medeiros; Sleiman, Hanan Khaled; Dal Forno, Gonzalo Ogliari; Romano, Marco Aurelio; Romano, Renata Marino.

Afiliação

Oliveira JM; Laboratory of Reproductive Toxicology, Department of Medicine, State University of Centro-Oeste (UNICENTRO), Rua Simeão Camargo Varela de Sa, 03, Zip-Code 85040-080, Parana, Brazil. Electronic address: jeaneoli.m@gmail.com.
Oliveira IM; Laboratory of Reproductive Toxicology, Department of Medicine, State University of Centro-Oeste (UNICENTRO), Rua Simeão Camargo Varela de Sa, 03, Zip-Code 85040-080, Parana, Brazil. Electronic address: medeiros_isabela@hotmail.com.
Sleiman HK; Laboratory of Reproductive Toxicology, Department of Medicine, State University of Centro-Oeste (UNICENTRO), Rua Simeão Camargo Varela de Sa, 03, Zip-Code 85040-080, Parana, Brazil. Electronic address: hanansleiman1987@gmail.com.
Dal Forno GO; Laboratory of Reproductive Toxicology, Department of Medicine, State University of Centro-Oeste (UNICENTRO), Rua Simeão Camargo Varela de Sa, 03, Zip-Code 85040-080, Parana, Brazil. Electronic address: gonzaloodf@gmail.com.
Romano MA; Laboratory of Reproductive Toxicology, Department of Medicine, State University of Centro-Oeste (UNICENTRO), Rua Simeão Camargo Varela de Sa, 03, Zip-Code 85040-080, Parana, Brazil. Electronic address: maromano17@unicentro.br.
Romano RM; Laboratory of Reproductive Toxicology, Department of Medicine, State University of Centro-Oeste (UNICENTRO), Rua Simeão Camargo Varela de Sa, 03, Zip-Code 85040-080, Parana, Brazil. Electronic address: romano@unicentro.br.

Toxicol Lett ; 369: 1-11, 2022 Oct 01.

Article em En | MEDLINE | ID: mdl-35963426

Assuntos

Hipogonadismo; Isoflavonas; Animais; Corticosterona; Estradiol/metabolismo; Hormônio Foliculoestimulante; Gonadotropinas Hipofisárias/metabolismo; Humanos; Hipogonadismo/metabolismo; Hipotálamo/metabolismo; Isoflavonas/farmacologia; Masculino; Fitoestrógenos/metabolismo; Fitoestrógenos/toxicidade; Puberdade; RNA Mensageiro/metabolismo; Ratos; Ratos Wistar; Testosterona

Palavras-chave

Developmental programming window; Hypogonadism; Male infertility; Male puberty; Reproductive development

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hipogonadismo / Isoflavonas Tipo de estudo: Etiology_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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