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Allosteric inhibitors targeting the calmodulin-PIP2 interface of SK4 K+ channels for atrial fibrillation treatment.
Burg, Shira; Shapiro, Shir; Peretz, Asher; Haimov, Elvira; Redko, Boris; Yeheskel, Adva; Simhaev, Luba; Engel, Hamutal; Raveh, Avi; Ben-Bassat, Ariel; Murninkas, Michael; Polak, Rotem; Haitin, Yoni; Etzion, Yoram; Attali, Bernard.
Afiliação
  • Burg S; Department of Physiology & Pharmacology, Tel Aviv University, Tel Aviv 69978, Israel.
  • Shapiro S; Cardiac Arrhythmia Research Laboratory, Department of Physiology and Cell Biology, Faculty of Health Sciences, Regenerative Medicine & Stem Cell Research Center, Ben-Gurion University of the Negev, Beer-Sheva, 8410501, Israel.
  • Peretz A; Department of Physiology & Pharmacology, Tel Aviv University, Tel Aviv 69978, Israel.
  • Haimov E; The Blavatnik Center for Drug Discovery, Tel Aviv University, Tel Aviv 69978, Israel.
  • Redko B; The Blavatnik Center for Drug Discovery, Tel Aviv University, Tel Aviv 69978, Israel.
  • Yeheskel A; The Blavatnik Center for Drug Discovery, Tel Aviv University, Tel Aviv 69978, Israel.
  • Simhaev L; The Blavatnik Center for Drug Discovery, Tel Aviv University, Tel Aviv 69978, Israel.
  • Engel H; The Blavatnik Center for Drug Discovery, Tel Aviv University, Tel Aviv 69978, Israel.
  • Raveh A; The Blavatnik Center for Drug Discovery, Tel Aviv University, Tel Aviv 69978, Israel.
  • Ben-Bassat A; The Laboratory of Structural Physiology of the Sackler Faculty of Medicine and Sagol School of Neurosciences, Tel Aviv University, Tel Aviv 69978, Israel.
  • Murninkas M; Cardiac Arrhythmia Research Laboratory, Department of Physiology and Cell Biology, Faculty of Health Sciences, Regenerative Medicine & Stem Cell Research Center, Ben-Gurion University of the Negev, Beer-Sheva, 8410501, Israel.
  • Polak R; Cardiac Arrhythmia Research Laboratory, Department of Physiology and Cell Biology, Faculty of Health Sciences, Regenerative Medicine & Stem Cell Research Center, Ben-Gurion University of the Negev, Beer-Sheva, 8410501, Israel.
  • Haitin Y; The Laboratory of Structural Physiology of the Sackler Faculty of Medicine and Sagol School of Neurosciences, Tel Aviv University, Tel Aviv 69978, Israel.
  • Etzion Y; Cardiac Arrhythmia Research Laboratory, Department of Physiology and Cell Biology, Faculty of Health Sciences, Regenerative Medicine & Stem Cell Research Center, Ben-Gurion University of the Negev, Beer-Sheva, 8410501, Israel.
  • Attali B; Regenerative Medicine & Stem Cell Research Center, Ben-Gurion University of the Negev, Beer-Sheva, 8410501, Israel.
Proc Natl Acad Sci U S A ; 119(34): e2202926119, 2022 08 23.
Article em En | MEDLINE | ID: mdl-35969786
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fibrilação Atrial / Calmodulina / Bloqueadores dos Canais de Potássio / Canais de Potássio Ativados por Cálcio de Condutância Intermediária Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fibrilação Atrial / Calmodulina / Bloqueadores dos Canais de Potássio / Canais de Potássio Ativados por Cálcio de Condutância Intermediária Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article