The Azithromycin Pro-Drug CSY5669 Boosts Bacterial Killing While Attenuating Lung Inflammation Associated with Pneumonia Caused by Methicillin-Resistant Staphylococcus aureus.

Saris, Anno; Qin, Wanhai; van Linge, Christine C A; Reijnders, Tom D Y; Florquin, Sandrine; Burnet, Michael; Strass, Simon; de Vos, Alex F; van der Poll, Tom

Saris, Anno; Qin, Wanhai; van Linge, Christine C A; Reijnders, Tom D Y; Florquin, Sandrine; Burnet, Michael; Strass, Simon; de Vos, Alex F; van der Poll, Tom.

Afiliação

Saris A; Center for Experimental and Molecular Medicine, Amsterdam University Medical Centers, Academic Medical Centergrid.5650.6, University of Amsterdam, Amsterdam, the Netherlands.
Qin W; Department of Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.
van Linge CCA; Center for Experimental and Molecular Medicine, Amsterdam University Medical Centers, Academic Medical Centergrid.5650.6, University of Amsterdam, Amsterdam, the Netherlands.
Reijnders TDY; Center for Experimental and Molecular Medicine, Amsterdam University Medical Centers, Academic Medical Centergrid.5650.6, University of Amsterdam, Amsterdam, the Netherlands.
Florquin S; Center for Experimental and Molecular Medicine, Amsterdam University Medical Centers, Academic Medical Centergrid.5650.6, University of Amsterdam, Amsterdam, the Netherlands.
Burnet M; Department of Pathology, Amsterdam University Medical Centers, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
Strass S; Synovo GmbH, Tübingen, Germany.
de Vos AF; Synovo GmbH, Tübingen, Germany.
van der Poll T; Department of Pharmaceutical Sciences, Eberhard-Karls-University Tübingen, Tübingen, Germany.

Antimicrob Agents Chemother ; 66(9): e0229821, 2022 09 20.

Article em En | MEDLINE | ID: mdl-35972289

Assuntos

Staphylococcus aureus Resistente à Meticilina; Pneumonia Estafilocócica; Pró-Fármacos; Infecções Estafilocócicas; Animais; Antibacterianos/farmacologia; Antibacterianos/uso terapêutico; Azitromicina/farmacologia; Azitromicina/uso terapêutico; Citocinas; Inflamação/tratamento farmacológico; Camundongos; Testes de Sensibilidade Microbiana; Óxido Nítrico; Pneumonia Estafilocócica/tratamento farmacológico; Pró-Fármacos/uso terapêutico; Espécies Reativas de Oxigênio; Infecções Estafilocócicas/tratamento farmacológico; Staphylococcus aureus

Palavras-chave

MRSA; Staphylococcus aureus; drug resistance; host directed therapies; host-pathogen interactions; immune response

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pneumonia Estafilocócica / Infecções Estafilocócicas / Pró-Fármacos / Staphylococcus aureus Resistente à Meticilina Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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