miR-222-3p-containing macrophage-derived extracellular vesicles confer gemcitabine resistance via TSC1-mediated mTOR/AKT/PI3K pathway in pancreatic cancer.

Guo, Yao; Wu, Heshui; Xiong, Jiongxin; Gou, Shanmiao; Cui, Jing; Peng, Tao

Guo, Yao; Wu, Heshui; Xiong, Jiongxin; Gou, Shanmiao; Cui, Jing; Peng, Tao.

Afiliação

Guo Y; Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Avenue, Wuhan, 430022, People's Republic of China.
Wu H; Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Avenue, Wuhan, 430022, People's Republic of China.
Xiong J; Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Avenue, Wuhan, 430022, People's Republic of China.
Gou S; Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Avenue, Wuhan, 430022, People's Republic of China.
Cui J; Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Avenue, Wuhan, 430022, People's Republic of China. cuijingjj@aliyun.com.
Peng T; Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Avenue, Wuhan, 430022, People's Republic of China. pengtao8815@hust.edu.cn.

Cell Biol Toxicol ; 39(4): 1203-1214, 2023 08.

Article em En | MEDLINE | ID: mdl-35974258

Assuntos

Vesículas Extracelulares; MicroRNAs; Neoplasias Pancreáticas; Animais; Camundongos; Gencitabina; MicroRNAs/genética; MicroRNAs/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Fosfatidilinositol 3-Quinases/metabolismo; Linhagem Celular Tumoral; Neoplasias Pancreáticas/tratamento farmacológico; Neoplasias Pancreáticas/genética; Serina-Treonina Quinases TOR/metabolismo; Macrófagos/metabolismo; Neoplasias Pancreáticas

Palavras-chave

Drug resistance; Extracellular vesicles; Gemcitabine; M2 macrophages; MicroRNA-222-3p; Pancreatic cancer; TSC1

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / MicroRNAs / Vesículas Extracelulares Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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