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Viral Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Omicron Infection in mRNA-Vaccinated Individuals Treated and Not Treated with Nirmatrelvir-Ritonavir.
Dai, Eric Y; Lee, Kannon A; Nathanson, Audrey B; Leonelli, Ariana T; Petros, Brittany A; Brock-Fisher, Taylor; Dobbins, Sabrina T; MacInnis, Bronwyn L; Capone, Amelia; Littlehale, Nancy; Boucau, Julie; Marino, Caitlin; Barczak, Amy K; Sabeti, Pardis C; Springer, Michael; Stephenson, Kathryn E.
Afiliação
  • Dai EY; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Lee KA; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Nathanson AB; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Leonelli AT; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Petros BA; Department of Systems Biology, Harvard Medical School, Boston, MA, USA.
  • Brock-Fisher T; Harvard-MIT MD/PhD Program, Boston, MA, USA.
  • Dobbins ST; Harvard-MIT Program in Health Sciences and Technology, Cambridge, MA.
  • MacInnis BL; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.
  • Capone A; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.
  • Littlehale N; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.
  • Boucau J; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.
  • Marino C; Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • Barczak AK; Beth Israel Lahey Health Primary Care, Chelsea, MA, USA.
  • Sabeti PC; Beth Israel Lahey Health Primary Care, Chelsea, MA, USA.
  • Springer M; Ragon Institute of Massachusetts General Hospital (MGH), Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.
  • Stephenson KE; Ragon Institute of Massachusetts General Hospital (MGH), Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.
medRxiv ; 2022 Aug 04.
Article em En | MEDLINE | ID: mdl-35982651
ABSTRACT
We measured viral kinetics of SARS-CoV-2 Omicron infection in 36 mRNA-vaccinated individuals, 11 of whom were treated with nirmatrelvir-ritonavir (NMV-r). We found that NMV-r was associated with greater incidence of viral rebound compared to no treatment. For those that did not rebound, NMV-r significantly reduced time to PCR conversion.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article