Unexpected structures formed by the kinase RET C634R mutant extracellular domain suggest potential oncogenic mechanisms in MEN2A.

Liu, Yixin; De Castro Ribeiro, Orquidea; Haapanen, Outi; Craven, Gregory B; Sharma, Vivek; Muench, Stephen P; Goldman, Adrian

Liu, Yixin; De Castro Ribeiro, Orquidea; Haapanen, Outi; Craven, Gregory B; Sharma, Vivek; Muench, Stephen P; Goldman, Adrian.

Afiliação

Liu Y; Molecular and Integrative Biosciences, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland.
De Castro Ribeiro O; Molecular and Integrative Biosciences, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland.
Haapanen O; Department of Physics, University of Helsinki, Helsinki, Finland.
Craven GB; School of Biomedical Sciences, Faculty of Biological Sciences & Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, United Kingdom.
Sharma V; Department of Physics, University of Helsinki, Helsinki, Finland; HiLIFE Institute of Biotechnology, University of Helsinki, Helsinki, Finland.
Muench SP; School of Biomedical Sciences, Faculty of Biological Sciences & Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, United Kingdom.
Goldman A; Molecular and Integrative Biosciences, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland; School of Biomedical Sciences, Faculty of Biological Sciences & Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, United Kingdom. Ele

J Biol Chem ; 298(10): 102380, 2022 10.

Article em En | MEDLINE | ID: mdl-35985422

Assuntos

Carcinogênese; Neoplasia Endócrina Múltipla Tipo 2a; Proteínas Proto-Oncogênicas c-ret; Humanos; Ligantes; Neoplasia Endócrina Múltipla Tipo 2a/genética; Neoplasia Endócrina Múltipla Tipo 2a/metabolismo; Mutação Puntual; Domínios Proteicos; Multimerização Proteica; Proteínas Proto-Oncogênicas c-ret/química; Proteínas Proto-Oncogênicas c-ret/genética; Cisteína/química; Cisteína/genética; Arginina/química; Arginina/genética

Palavras-chave

GDF15; GDNF; GFRAL; GFRα1; MEN2A; RET; RET C634R mutant; membrane protein; protein-protein interaction

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasia Endócrina Múltipla Tipo 2a / Proteínas Proto-Oncogênicas c-ret / Carcinogênese Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google