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Injectable magnetic montmorillonite colloidal gel for the postoperative treatment of hepatocellular carcinoma.
Chen, Sheng; Song, Yonghong; Yan, Xu; Dong, Liang; Xu, Yunjun; Xuan, Shouhu; Shu, Quan; Cao, Baoqiang; Hu, Jinlong; Xing, Hanye; Wu, Wenshu; Zha, Zhengbao; Lu, Yang.
Afiliação
  • Chen S; Anhui Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering, School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, China.
  • Song Y; Anhui Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering, School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, China.
  • Yan X; Anhui Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering, School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, China.
  • Dong L; Division of Nanomaterials & Chemistry, Department of Modern Mechanics, Department of Radiology, Hefei National Laboratory for Physical Sciences at the Microscale, The First Affiliated Hospital of University of Science and Technology of China, University of Science and Technology of China, Hefei,
  • Xu Y; Chinese Academy of Sciences, Institute of Basic Medicine and Cancer (IBMC), The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, 310022, Zhejiang, China. dldisc@ustc.edu.cn.
  • Xuan S; Division of Nanomaterials & Chemistry, Department of Modern Mechanics, Department of Radiology, Hefei National Laboratory for Physical Sciences at the Microscale, The First Affiliated Hospital of University of Science and Technology of China, University of Science and Technology of China, Hefei,
  • Shu Q; Division of Nanomaterials & Chemistry, Department of Modern Mechanics, Department of Radiology, Hefei National Laboratory for Physical Sciences at the Microscale, The First Affiliated Hospital of University of Science and Technology of China, University of Science and Technology of China, Hefei,
  • Cao B; Division of Nanomaterials & Chemistry, Department of Modern Mechanics, Department of Radiology, Hefei National Laboratory for Physical Sciences at the Microscale, The First Affiliated Hospital of University of Science and Technology of China, University of Science and Technology of China, Hefei,
  • Hu J; Department of General Surgery, Department of Ultrasonics, Department of Interventional Radiology, Anhui No. 2 Provincial People's Hospital, Hefei, 230041, Anhui, China.
  • Xing H; Department of General Surgery, Department of Ultrasonics, Department of Interventional Radiology, Anhui No. 2 Provincial People's Hospital, Hefei, 230041, Anhui, China.
  • Wu W; Anhui Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering, School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, China.
  • Zha Z; Anhui Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering, School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, China.
  • Lu Y; Anhui Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering, School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, China. zbzha@hfut.edu.cn.
J Nanobiotechnology ; 20(1): 381, 2022 Aug 19.
Article em En | MEDLINE | ID: mdl-35986283
ABSTRACT
Bioactive materials have been extensively developed for the adjuvant therapy of cancer. However, few materials can meet the requirements for the postoperative resection of hepatocellular carcinoma (HCC) due to massive bleeding and high recurrence. In particular, combination therapy for HCC has been highly recommended in clinical practice, including surgical resection, interventional therapy, ablation therapy and chemotherapy. Herein, an injectable magnetic colloidal gel (MCG) was developed by controllable electrostatic attraction between clinically available magnetic montmorillonites and amphoteric gelatin nanoparticles. The optimized MCG exhibited an effective magnetic heating effect, remarkable rheological properties, and high gel network stability, realizing the synergistic treatment of postoperative HCC by stimuli-responsive drug delivery, hemostasis and magnetic hyperthermia. Furthermore, a minimal invasive MCG-induced interventional magnetic hyperthermia therapy (MHT) under ultrasound guidance was realized on hepatic tumor rabbits, providing an alternative therapeutics to treat the postoperative recurrence. Overall, MCG is a clinically available injectable formulation for adjuvant therapy after HCC surgical resection.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma Hepatocelular / Hipertermia Induzida / Neoplasias Hepáticas Tipo de estudo: Guideline Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma Hepatocelular / Hipertermia Induzida / Neoplasias Hepáticas Tipo de estudo: Guideline Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article