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Association between white matter lesions and Parkinson's disease: an impact on Postural/Gait difficulty phenotype and cognitive performance.
Sinani, Olga; Dadouli, Katerina; Ntellas, Panagiotis; Kapsalaki, Eftychia Z; Vlychou, Marianna; Raptis, Dimitrios G; Marogianni, Chrysoula; Markou, Katerina; Dardiotis, Efthimios; Xiromerisiou, Georgia.
Afiliação
  • Sinani O; Faculty of Medicine, University of Thessaly, Larisa, Greece.
  • Dadouli K; Laboratory of Hygiene and Epidemiology, Faculty of Medicine, University of Thessaly, Larisa, Greece.
  • Ntellas P; Department of Medical Oncology, University Hospital of Ioannina, Ioannina, Greece.
  • Kapsalaki EZ; Department of Diagnostic Radiology, Faculty of Medicine, University of Thessaly, Larisa, Greece.
  • Vlychou M; Department of Diagnostic Radiology, Faculty of Medicine, University of Thessaly, Larisa, Greece.
  • Raptis DG; Respiratory Medicine Department, Faculty of Medicine, University of Thessaly, Larisa, Greece.
  • Marogianni C; Faculty of Medicine, University of Thessaly, Larisa, Greece.
  • Markou K; Department of Neurology, University Hospital of Larisa, Larisa, Greece.
  • Dardiotis E; Department of Neurology, University Hospital of Larisa, Larisa, Greece.
  • Xiromerisiou G; Department of Neurology, University Hospital of Larisa, Larisa, Greece.
Neurol Res ; 44(12): 1122-1131, 2022 Dec.
Article em En | MEDLINE | ID: mdl-35994524
BACKGROUND: White matter hyperintensities (WMHs) may be observed on Magnetic Resonance Imaging (MRI) in patients with Parkinson disease with or without vascular risk factors. Whether WMHs may influence motor and non-motor aspects of Parkinson disease is a subject of debate. The aim of this study is to evaluate the impact of WMH severity on various aspects of Parkinson disease in combination to the estimation of the impact of cerebrovascular risk factors. MATERIALS AND METHODS: We included a cohort of patients with Parkinson's disease who underwent MRI examination. The Fazekas visual rating scale was used to assess the severity and location of WMHs, and patient clinical characteristics were correlated with MRI data. RESULTS: All vascular risk factors were associated with higher Fazekas score in both periventricular and deep white matter. Periventricular white matter hyperintensities (PWMHs) and deep white matter hyperintensities (DWMHs) were associated with lower scores in the ACE-R cognitive assessment scale (p < 0.001). Furthermore, PWMHs and DWMHs severity was associated with higher UPDRS motor score (p < 0.001), while the Postural Instability Gait Difficulty (PIGD) phenotype was correlated with higher burden of WMHs. CONCLUSIONS: Comorbid WMHs may contribute to multi-dimension dysfunction in patients with Parkinson disease and consequently the management of vascular risk factors may be crucial to maintain motor and non-motor functions in PD.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Substância Branca Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Substância Branca Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article