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13-amino derivatives of dehydrocostus lactone display greatly enhanced selective toxicity against breast cancer cells and improved binding energies to protein kinases in silico.
Kemboi, Douglas; Langat, Moses K; Siwe-Noundou, Xavier; Tshiwawa, Tendamudzimu; Krause, Rui W M; Davison, Candace; Smit, Christie Jane; de la Mare, Jo-Anne; Tembu, Vuyelwa Jacqueline.
Afiliação
  • Kemboi D; Department of Chemistry, Tshwane University of Technology, Pretoria, South Africa.
  • Langat MK; Department of Chemistry, Rhodes University, Makhanda (Grahamstown), South Africa.
  • Siwe-Noundou X; Royal Botanic Gardens Kew, Kew Green, Richmond, Surrey, United Kingdom.
  • Tshiwawa T; Pharmaceutical Sciences Department, Sefako Makgatho Health Sciences University, Pretoria, South Africa.
  • Krause RWM; Department of Chemistry, Rhodes University, Makhanda (Grahamstown), South Africa.
  • Davison C; Department of Chemistry, Rhodes University, Makhanda (Grahamstown), South Africa.
  • Smit CJ; Department of Biochemistry and Microbiology, Rhodes University, Makhanda (Grahamstown), South Africa.
  • de la Mare JA; Department of Biochemistry and Microbiology, Rhodes University, Makhanda (Grahamstown), South Africa.
  • Tembu VJ; Department of Biochemistry and Microbiology, Rhodes University, Makhanda (Grahamstown), South Africa.
PLoS One ; 17(8): e0271389, 2022.
Article em En | MEDLINE | ID: mdl-35998145
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias de Mama Triplo Negativas / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias de Mama Triplo Negativas / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article