Visible-light photocatalytic radical addition-translocation-cyclization to construct sulfonyl-containing azacycles.
Chem Commun (Camb)
; 58(73): 10206-10209, 2022 Sep 13.
Article
em En
| MEDLINE
| ID: mdl-36000456
ABSTRACT
Herein, a novel visible-light photocatalytic radical addition-translocation-cyclization (RATC) approach for the efficient synthesis of sulfonyl-containing azacycles is described. The reaction delivers a wide range of monocyclic, bicyclic and polycyclic azacycles by using easily prepared sodium sulfinates and N-homopropargylic amines as starting materials. Instead of the traditionally used toxic tin reagents and thermally hazardous azos in the RATC process, clean, renewable and sustainable visible light combined with a catalytic amount of photosensitizer is used in this process. Moreover, the successful transformation of some drug derivatives further highlights the potential application of this procedure.
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Ano de publicação:
2022
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Article