Single-molecule imaging reveals Tau trapping at nanometer-sized dynamic hot spots near the plasma membrane that persists after microtubule perturbation and cholesterol depletion.

Padmanabhan, Pranesh; Kneynsberg, Andrew; Cruz, Esteban; Amor, Rumelo; Sibarita, Jean-Baptiste; Götz, Jürgen

Padmanabhan, Pranesh; Kneynsberg, Andrew; Cruz, Esteban; Amor, Rumelo; Sibarita, Jean-Baptiste; Götz, Jürgen.

Afiliação

Padmanabhan P; Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.
Kneynsberg A; Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.
Cruz E; Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.
Amor R; Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.
Sibarita JB; Université de Bordeaux, Interdisciplinary Institute for Neuroscience, UMR, Bordeaux, France.
Götz J; Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.

EMBO J ; 41(19): e111265, 2022 10 04.

Article em En | MEDLINE | ID: mdl-36004506

Assuntos

Microtúbulos; Imagem Individual de Molécula; Membrana Celular/metabolismo; Cinética; Microtúbulos/metabolismo; Proteínas tau/metabolismo

Palavras-chave

Alzheimer's disease; Tau; nanodomains; single-molecule imaging; super-resolution microscopy

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Imagem Individual de Molécula / Microtúbulos Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Imagem Individual de Molécula / Microtúbulos Idioma: En Ano de publicação: 2022 Tipo de documento: Article