Different Protein Sources Enhance 18FDG-PET/MR Uptake of Brown Adipocytes in Male Subjects.
Nutrients
; 14(16)2022 Aug 19.
Article
em En
| MEDLINE
| ID: mdl-36014915
ABSTRACT
BACKGROUND:
The unique ability of brown adipocytes to increase metabolic rate suggests that they could be targeted as an obesity treatment.OBJECTIVE:
The objective of the study was to search for new dietary factors that may enhance brown adipose tissue (BAT) activity.METHODS:
The study group comprised 28 healthy non-smoking males, aged 21-42 years old. All volunteers underwent a physical examination and a 75 g oral glucose tolerance test (75g-OGTT). Serum atrial and brain natriuretic peptide (ANP, BNP), PRD1-BF1-RIZ1 homologous domain containing 16 (PRDM16) and eukaryotic translation initiation factor 4E (eIF4E) measurements were taken, and 3-day food intake diaries were completed. Body composition measurements were assessed using dual-energy X-ray absorptiometry (DXA) scanning and bioimpedance methods. An fluorodeoxyglucose-18 (FDG-18) uptake in BAT was assessed by positron emission tomography/magnetic resonance (PET/MR) in all participants after 2 h cold exposure. The results were adjusted for age, daily energy intake, and DXA lean mass.RESULTS:
Subjects with detectable BAT (BAT(+)) were characterized by a higher percentage of energy obtained from dietary protein and fat and higher muscle mass (p = 0.01, p = 0.02 and p = 0.04, respectively). In the BAT(+) group, animal protein intake was positively associated (p= 0.04), whereas the plant protein intake negatively correlated with BAT activity (p = 0.03). Additionally, the presence of BAT was inversely associated with BNP concentration in the 2 h of cold exposure (p = 0.002).CONCLUSION:
The outcomes of our study suggest that different macronutrient consumption may be a new way to modulate BAT activity leading to weight reduction.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Fluordesoxiglucose F18
/
Adipócitos Marrons
Limite:
Animals
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Humans
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Male
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article