Your browser doesn't support javascript.
loading
Elevated Fasting Blood Glucose Levels Are Associated with Worse Clinical Outcomes in COVID-19 Patients Than in Pneumonia Patients with Bacterial Infections.
Wang, Wenjun; Chai, Zhonglin; Cooper, Mark E; Zimmet, Paul Z; Guo, Hua; Ding, Junyu; Yang, Feifei; Lin, Xixiang; Chen, Xu; Wang, Xiao; Zhong, Qin; Li, Zongren; Zhang, Peifang; Wu, Zhenzhou; Guan, Xizhou; Zhang, Lei; He, Kunlun.
Afiliação
  • Wang W; Key Laboratory of Ministry of Industry and Information Technology of Biomedical Engineering and Translational Medicine, Chinese PLA, General Hospital, Beijing 100853, China.
  • Chai Z; Beijing Key Laboratory for Precision Medicine of Chronic Heart Failure, Chinese PLA, General Hospital, Beijing 100853, China.
  • Cooper ME; Medical Big Data Research Center, Chinese PLA, General Hospital, Beijing 100853, China.
  • Zimmet PZ; Central Clinical School, Faculty of Medicine, Monash University, Melbourne 3004, Australia.
  • Guo H; Central Clinical School, Faculty of Medicine, Monash University, Melbourne 3004, Australia.
  • Ding J; Central Clinical School, Faculty of Medicine, Monash University, Melbourne 3004, Australia.
  • Yang F; Department of Pulmonary and Critical Care Medicine, Chinese PLA, General Hospital, Beijing 100853, China.
  • Lin X; Department of Pulmonary and Critical Care Medicine, Chinese PLA, General Hospital, Beijing 100853, China.
  • Chen X; Key Laboratory of Ministry of Industry and Information Technology of Biomedical Engineering and Translational Medicine, Chinese PLA, General Hospital, Beijing 100853, China.
  • Wang X; Beijing Key Laboratory for Precision Medicine of Chronic Heart Failure, Chinese PLA, General Hospital, Beijing 100853, China.
  • Zhong Q; Medical Big Data Research Center, Chinese PLA, General Hospital, Beijing 100853, China.
  • Li Z; Key Laboratory of Ministry of Industry and Information Technology of Biomedical Engineering and Translational Medicine, Chinese PLA, General Hospital, Beijing 100853, China.
  • Zhang P; Beijing Key Laboratory for Precision Medicine of Chronic Heart Failure, Chinese PLA, General Hospital, Beijing 100853, China.
  • Wu Z; Medical Big Data Research Center, Chinese PLA, General Hospital, Beijing 100853, China.
  • Guan X; Key Laboratory of Ministry of Industry and Information Technology of Biomedical Engineering and Translational Medicine, Chinese PLA, General Hospital, Beijing 100853, China.
  • Zhang L; Beijing Key Laboratory for Precision Medicine of Chronic Heart Failure, Chinese PLA, General Hospital, Beijing 100853, China.
  • He K; Medical Big Data Research Center, Chinese PLA, General Hospital, Beijing 100853, China.
Pathogens ; 11(8)2022 Aug 10.
Article em En | MEDLINE | ID: mdl-36015023
Aims: We investigate how fasting blood glucose (FBG) levels affect the clinical severity in coronavirus disease 2019 (COVID-19) patients, pneumonia patients with sole bacterial infection, and pneumonia patients with concurrent bacterial and fungal infections. Methods: We enrolled 2761 COVID-19 patients, 1686 pneumonia patients with bacterial infections, and 2035 pneumonia patients with concurrent infections. We used multivariate logistic regression analysis to assess the associations between FBG levels and clinical severity. Results: FBG levels in COVID-19 patients were significantly higher than in other pneumonia patients during hospitalisation and at discharge (all p < 0.05). Among COVID-19 patients, the odds ratios of acute respiratory distress syndrome (ARDS), respiratory failure (RF), acute hepatitis/liver failure (AH/LF), length of stay, and intensive care unit (ICU) admission were 12.80 (95% CI, 4.80−37.96), 5.72 (2.95−11.06), 2.60 (1.20−5.32), 1.42 (1.26−1.59), and 5.16 (3.26−8.17) times higher in the FBG ≥7.0 mmol/L group than in FBG < 6.1 mmol/L group, respectively. The odds ratios of RF, AH/LF, length of stay, and ICU admission were increased to a lesser extent in pneumonia patients with sole bacterial infection (3.70 [2.21−6.29]; 1.56 [1.17−2.07]; 0.98 [0.88−1.11]; 2.06 [1.26−3.36], respectively). The odds ratios of ARDS, RF, AH/LF, length of stay, and ICU admission were increased to a lesser extent in pneumonia patients with concurrent infections (3.04 [0.36−6.41]; 2.31 [1.76−3.05]; 1.21 [0.97−1.52]; 1.02 [0.93−1.13]; 1.72 [1.19−2.50], respectively). Among COVID-19 patients, the incidence rate of ICU admission on day 21 in the FBG ≥ 7.0 mmol/L group was six times higher than in the FBG < 6.1 mmol/L group (12.30% vs. 2.21%, p < 0.001). Among other pneumonia patients, the incidence rate of ICU admission on day 21 was only two times higher. Conclusions: Elevated FBG levels at admission predict subsequent clinical severity in all pneumonia patients regardless of the underlying pathogens, but COVID-19 patients are more sensitive to FBG levels, and suffer more severe clinical complications than other pneumonia patients.
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Ano de publicação: 2022 Tipo de documento: Article