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Intergrader agreement of foveal cone topography measured using adaptive optics scanning light ophthalmoscopy.
Wynne, Niamh; Cava, Jenna A; Gaffney, Mina; Heitkotter, Heather; Scheidt, Abigail; Reiniger, Jenny L; Grieshop, Jenna; Yang, Kai; Harmening, Wolf M; Cooper, Robert F; Carroll, Joseph.
Afiliação
  • Wynne N; Department of Ophthalmology and Visual Sciences, Medical College of Wisconsin, 8701 W Watertown Plank Rd, Milwaukee, WI 53226, USA.
  • Cava JA; Department of Ophthalmology and Visual Sciences, Medical College of Wisconsin, 8701 W Watertown Plank Rd, Milwaukee, WI 53226, USA.
  • Gaffney M; Joint Department of Biomedical Engineering, Medical College of Wisconsin and Marquette University, 1250 W Wisconsin Ave, Milwaukee, WI 53233, USA.
  • Heitkotter H; Department of Cell Biology, Neurobiology and Anatomy, 8701 W Watertown Plank Rd, Milwaukee, WI 53226, USA.
  • Scheidt A; Department of Ophthalmology and Visual Sciences, Medical College of Wisconsin, 8701 W Watertown Plank Rd, Milwaukee, WI 53226, USA.
  • Reiniger JL; Department of Ophthalmology, University of Bonn, Ernst-Abbe-Str. 2, 53127 Bonn, Germany.
  • Grieshop J; Joint Department of Biomedical Engineering, Medical College of Wisconsin and Marquette University, 1250 W Wisconsin Ave, Milwaukee, WI 53233, USA.
  • Yang K; Division of Biostatistics, Medical College of Wisconsin, 8701 W Watertown Plank Rd, Milwaukee, WI 53226, USA.
  • Harmening WM; Department of Ophthalmology, University of Bonn, Ernst-Abbe-Str. 2, 53127 Bonn, Germany.
  • Cooper RF; Department of Ophthalmology and Visual Sciences, Medical College of Wisconsin, 8701 W Watertown Plank Rd, Milwaukee, WI 53226, USA.
  • Carroll J; Joint Department of Biomedical Engineering, Medical College of Wisconsin and Marquette University, 1250 W Wisconsin Ave, Milwaukee, WI 53233, USA.
Biomed Opt Express ; 13(8): 4445-4454, 2022 Aug 01.
Article em En | MEDLINE | ID: mdl-36032569
ABSTRACT
The foveal cone mosaic can be directly visualized using adaptive optics scanning light ophthalmoscopy (AOSLO). Previous studies in individuals with normal vision report wide variability in the topography of the foveal cone mosaic, especially the value of peak cone density (PCD). While these studies often involve a human grader, there have been no studies examining intergrader reproducibility of foveal cone mosaic metrics. Here we re-analyzed published AOSLO foveal cone images from 44 individuals to assess the relationship between the cone density centroid (CDC) location and the location of PCD. Across 5 graders with variable experience, we found a measurement error of 11.7% in PCD estimates and higher intergrader reproducibility of CDC location compared to PCD location (p < 0.0001). These estimates of measurement error can be used in future studies of the foveal cone mosaic, and our results support use of the CDC location as a more reproducible anchor for cross-modality analyses.

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article