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Within-subject biological variation estimates using an indirect data mining strategy. Spanish multicenter pilot study (BiVaBiDa).
Marqués-García, Fernando; Nieto-Librero, Ana; González-García, Nerea; Galindo-Villardón, Purificación; Martínez-Sánchez, Luisa María; Tejedor-Ganduxé, Xavier; Boned, Beatriz; Muñoz-Calero, María; García-Lario, Jose-Vicente; González-Lao, Elisabet; González-Tarancón, Ricardo; Fernández-Fernández, M Pilar; Perich, Maria Carmen; Simón, Margarida; Díaz-Garzón, Jorge; Fernández-Calle, Pilar.
Afiliação
  • Marqués-García F; Clinical Biochemistry Department, Metropolitan North Clinical Laboratory (LUMN), Germans Trias i Pujol University Hospital, Barcelona, Spain.
  • Nieto-Librero A; Spanish Society of Laboratory Medicine (SEQC), Analytical Quality Commission, Barcelona, Spain.
  • González-García N; Statistics Department, Medicine Faculty, University of Salamanca, Salamanca, Spain.
  • Galindo-Villardón P; Statistics Department, Medicine Faculty, University of Salamanca, Salamanca, Spain.
  • Martínez-Sánchez LM; Statistics Department, Medicine Faculty, University of Salamanca, Salamanca, Spain.
  • Tejedor-Ganduxé X; Spanish Society of Laboratory Medicine (SEQC), Analytical Quality Commission, Barcelona, Spain.
  • Boned B; Biochemistry Department, Clinical Laboratories and Clinical Biochemistry Group Vall d'Hebron Institute of Research, Vall d'Hebron University Hospital, Barcelona, Spain.
  • Muñoz-Calero M; Clinical Biochemistry Department, Metropolitan North Clinical Laboratory (LUMN), Germans Trias i Pujol University Hospital, Barcelona, Spain.
  • García-Lario JV; Spanish Society of Laboratory Medicine (SEQC), Analytical Quality Commission, Barcelona, Spain.
  • González-Lao E; Spanish Society of Laboratory Medicine (SEQC), Analytical Quality Commission, Barcelona, Spain.
  • González-Tarancón R; Royo Villanova Hospital, Zaragoza, Spain.
  • Fernández-Fernández MP; Spanish Society of Laboratory Medicine (SEQC), Analytical Quality Commission, Barcelona, Spain.
  • Perich MC; Reina Sofia University Hospital, Córdoba, Spain.
  • Simón M; Spanish Society of Laboratory Medicine (SEQC), Analytical Quality Commission, Barcelona, Spain.
  • Díaz-Garzón J; San Cecilio University Hospital, Granada, Spain.
  • Fernández-Calle P; Spanish Society of Laboratory Medicine (SEQC), Analytical Quality Commission, Barcelona, Spain.
Clin Chem Lab Med ; 60(11): 1804-1812, 2022 10 26.
Article em En | MEDLINE | ID: mdl-36036462
ABSTRACT

OBJECTIVES:

The estimates of biological variation (BV) have traditionally been determined using direct methods, which present limitations. In response to this issue, two papers have been published addressing these limitations by employing indirect methods. Here, we present a new procedure, based on indirect methods that analyses data collected within a multicenter pilot study. Using this method, we obtain CVI estimates and calculate confidence intervals (CI), using the EFLM-BVD CVI estimates as gold standard for comparison.

METHODS:

Data were collected over a 18-month period for 7 measurands, from 3 Spanish hospitals; inclusion criteria patients 18-75 years with more than two determinations. For each measurand, four different strategies were carried out based on the coefficient of variation ratio (rCoeV) and based on the use of the bootstrap method (OS1, RS2 and RS3). RS2 and RS3 use symmetry reference change value (RCV) to clean database.

RESULTS:

RS2 and RS3 had the best correlation for the CVI estimates with respect to EFLM-BVD. RS2 used the symmetric RCV value without eliminating outliers, while RS3 combined RCV and outliers. When using the rCoeV and OS1 strategies, an overestimation of the CVI value was obtained.

CONCLUSIONS:

Our study presents a new strategy for obtaining robust CVI estimates using an indirect method together with the value of symmetric RCV to select the target population. The CVI estimates obtained show a good correlation with those published in the EFLM-BVD database. Furthermore, our strategy can resolve some of the limitations encountered when using direct methods such as calculating confidence intervals.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Mineração de Dados Tipo de estudo: Clinical_trials Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Mineração de Dados Tipo de estudo: Clinical_trials Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article