Notch signaling mutations increase intra-tumor chemokine expression and predict response to immunotherapy in colorectal cancer.

Wang, Fei; Huang, Chuan; Long, Jie; Zhao, Zhi-Bin; Ma, Hai-Qing; Yao, Xue-Qing; Li, Liang; Lian, Zhe-Xiong

Wang, Fei; Huang, Chuan; Long, Jie; Zhao, Zhi-Bin; Ma, Hai-Qing; Yao, Xue-Qing; Li, Liang; Lian, Zhe-Xiong.

Afiliação

Wang F; Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, Guangdong, China.
Huang C; Department of Oncology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, Guangdong, China.
Long J; School of Medicine, South China University of Technology, Guangzhou, 510006, Guangdong, China.
Zhao ZB; Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, Guangdong, China.
Ma HQ; Medical Research Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, Guangdong, China.
Yao XQ; Department of Oncology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, Guangdong, China. mahaiqing@gdph.org.cn.
Li L; Medical Research Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, Guangdong, China. mahaiqing@gdph.org.cn.
Lian ZX; Department of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, Guangdong, China. syyaoxueqing@scut.edu.cn.

BMC Cancer ; 22(1): 933, 2022 Aug 29.

Article em En | MEDLINE | ID: mdl-36038820

Assuntos

Neoplasias Colorretais; Quimiocinas/genética; Neoplasias Colorretais/tratamento farmacológico; Neoplasias Colorretais/terapia; Humanos; Inibidores de Checkpoint Imunológico; Imunoterapia; Instabilidade de Microssatélites; Mutação; Prognóstico; Transdução de Sinais/genética; Microambiente Tumoral/genética

Palavras-chave

Chemokine; Colorectal cancer; Immunotherapy; Mutation; Notch signaling

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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