ß-Sitosterol could serve as a dual inhibitor of Trypanosoma congolense sialidase and phospholipase A<sub>2</sub>: in vitro kinetic analyses and molecular dynamic simulations.

Aminu, Suleiman; Danazumi, Ammar Usman; Alhafiz, Zainab Aliyu; Gorna, Maria Wiktoria; Ibrahim, Mohammed Auwal

ß-Sitosterol could serve as a dual inhibitor of Trypanosoma congolense sialidase and phospholipase A₂: in vitro kinetic analyses and molecular dynamic simulations.

Aminu, Suleiman; Danazumi, Ammar Usman; Alhafiz, Zainab Aliyu; Gorna, Maria Wiktoria; Ibrahim, Mohammed Auwal.

Afiliação

Aminu S; Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria.
Danazumi AU; Biological and Chemical Research Center, Department of Chemistry, University of Warsaw, Warsaw, Poland.
Alhafiz ZA; Faculty of Chemistry, Warsaw University of Technology, Warsaw, Poland.
Gorna MW; Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria.
Ibrahim MA; Department of Biochemistry, Federal University, Gusau, Nigeria.

Mol Divers ; 27(4): 1645-1660, 2023 Aug.

Article em En | MEDLINE | ID: mdl-36042119

Assuntos

Trypanosoma congolense; Tripanossomíase Africana; Animais; Simulação de Dinâmica Molecular; Neuraminidase/química; Trypanosoma congolense/metabolismo; Simulação de Acoplamento Molecular; Cinética; Tripanossomíase Africana/tratamento farmacológico; Tripanossomíase Africana/veterinária; Fosfolipases/metabolismo; Fosfolipases/farmacologia

Palavras-chave

Anemia; Molecular dynamic simulation; Phospholipase A2; Sialidase; T. congolense; ß-sitosterol

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tripanossomíase Africana / Trypanosoma congolense Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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