Dexmedetomidine Confers Protection Against Neuronal Oxygen Glucose Deprivation-Reperfusion by Regulating SIRT3 Mediated Autophagy.

Fu, Zhijie; Pang, Zhilu; He, Long; Zhang, Le; Fan, Yuning; Zhao, Can; Yang, Jianjun

Fu, Zhijie; Pang, Zhilu; He, Long; Zhang, Le; Fan, Yuning; Zhao, Can; Yang, Jianjun.

Afiliação

Fu Z; Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, No. 1, Longhu Central Ring Road, Zhengzhou, 450000, Henan Province, China.
Pang Z; Department of Anesthesiology, Pain and Perioperative Medicine, Henan Provincial People's Hospital, Zhengzhou, 450000, China.
He L; Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, No. 1, Longhu Central Ring Road, Zhengzhou, 450000, Henan Province, China.
Zhang L; Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, No. 1, Longhu Central Ring Road, Zhengzhou, 450000, Henan Province, China.
Fan Y; Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, No. 1, Longhu Central Ring Road, Zhengzhou, 450000, Henan Province, China.
Zhao C; Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, No. 1, Longhu Central Ring Road, Zhengzhou, 450000, Henan Province, China.
Yang J; Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, No. 1, Longhu Central Ring Road, Zhengzhou, 450000, Henan Province, China. jianjunyang1971@126.com.

Neurochem Res ; 47(11): 3490-3505, 2022 Nov.

Article em En | MEDLINE | ID: mdl-36042140

Assuntos

Dexmedetomidina; Traumatismo por Reperfusão; Sirtuína 3; Proteínas Quinases Ativadas por AMP/metabolismo; Laranja de Acridina/metabolismo; Laranja de Acridina/farmacologia; Trifosfato de Adenosina/metabolismo; Apoptose; Autofagia; Proteínas Relacionadas à Autofagia/metabolismo; Dexmedetomidina/farmacologia; Glucose/metabolismo; Humanos; Peróxido de Hidrogênio/farmacologia; Neurônios/metabolismo; Oxigênio/metabolismo; Reperfusão; Traumatismo por Reperfusão/tratamento farmacológico; Traumatismo por Reperfusão/metabolismo; Traumatismo por Reperfusão/prevenção & controle; Transdução de Sinais; Sirtuína 3/metabolismo; Serina-Treonina Quinases TOR/metabolismo

Palavras-chave

AMPK; Autophagy; Dexmedetomidine; Oxygen glucose deprivation-reperfusion; SIRT3; mTOR pathway

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Traumatismo por Reperfusão / Dexmedetomidina / Sirtuína 3 Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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