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Gold nanoparticles bearing a clinically used non-antibiotic drug for combating multi-drug resistant bacteria.
Jia, Yuexiao; Zhang, Jiangjiang; Zhao, Yingcan; Dong, Ruihua; Wang, Hui; Jiang, Xingyu.
Afiliação
  • Jia Y; Guangdong Provincial Key Laboratory of Advanced Biomaterials, Shenzhen Key Laboratory of Smart Healthcare Engineering, Department of Biomedical Engineering, Southern University of Science and Technology, No. 1088, Xueyuan Rd., Xili, Nanshan District, Shenzhen, Guangdong, 518055, P. R. China.
  • Zhang J; Guangdong Provincial Key Laboratory of Advanced Biomaterials, Shenzhen Key Laboratory of Smart Healthcare Engineering, Department of Biomedical Engineering, Southern University of Science and Technology, No. 1088, Xueyuan Rd., Xili, Nanshan District, Shenzhen, Guangdong, 518055, P. R. China.
  • Zhao Y; Guangdong Provincial Key Laboratory of Advanced Biomaterials, Shenzhen Key Laboratory of Smart Healthcare Engineering, Department of Biomedical Engineering, Southern University of Science and Technology, No. 1088, Xueyuan Rd., Xili, Nanshan District, Shenzhen, Guangdong, 518055, P. R. China.
  • Dong R; Guangdong Provincial Key Laboratory of Advanced Biomaterials, Shenzhen Key Laboratory of Smart Healthcare Engineering, Department of Biomedical Engineering, Southern University of Science and Technology, No. 1088, Xueyuan Rd., Xili, Nanshan District, Shenzhen, Guangdong, 518055, P. R. China.
  • Wang H; Department of Clinical Laboratory, Peking University People's Hospital, Beijing 100044, P. R. China.
  • Jiang X; Guangdong Provincial Key Laboratory of Advanced Biomaterials, Shenzhen Key Laboratory of Smart Healthcare Engineering, Department of Biomedical Engineering, Southern University of Science and Technology, No. 1088, Xueyuan Rd., Xili, Nanshan District, Shenzhen, Guangdong, 518055, P. R. China.
Chem Commun (Camb) ; 58(75): 10544-10547, 2022 Sep 20.
Article em En | MEDLINE | ID: mdl-36047304
ABSTRACT
We introduce N-acetyl-L-cysteine (NAC), a clinically used non-antibiotic drug, to the synthesis of antibacterial gold nanoparticles (Au_NAC). Au_NAC shows excellent antibacterial activities against multi-drug resistant (MDR) Gram-negative bacteria and possesses wound healing capabilities. We provide a new direction for antibiotic design and novel uses of known drugs.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Nanopartículas Metálicas / Ouro Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Nanopartículas Metálicas / Ouro Idioma: En Ano de publicação: 2022 Tipo de documento: Article