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Development of 3α,7α-dihydroxy-6α-ethyl-24-nor-5ß-cholan-23-sulfate sodium salt (INT-767): Process optimization, synthesis and characterization of metabolites.
Cerra, Bruno; Venturoni, Francesco; Souma, Maria; Ceccarelli, Giada; Lozza, Anna Maria; Passeri, Daniela; De Franco, Francesca; Baxendale, Ian R; Pellicciari, Roberto; Macchiarulo, Antonio; Gioiello, Antimo.
Afiliação
  • Cerra B; Laboratory of Medicinal and Advanced Synthetic Chemistry, Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, 06122, Perugia, Italy.
  • Venturoni F; Laboratory of Medicinal and Advanced Synthetic Chemistry, Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, 06122, Perugia, Italy.
  • Souma M; Laboratory of Medicinal and Advanced Synthetic Chemistry, Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, 06122, Perugia, Italy.
  • Ceccarelli G; Laboratory of Medicinal and Advanced Synthetic Chemistry, Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, 06122, Perugia, Italy.
  • Lozza AM; Laboratory of Medicinal and Advanced Synthetic Chemistry, Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, 06122, Perugia, Italy.
  • Passeri D; TES Pharma, Via Palmiro Togliatti 20, 06073, Taverne di Corciano, Perugia, Italy.
  • De Franco F; TES Pharma, Via Palmiro Togliatti 20, 06073, Taverne di Corciano, Perugia, Italy.
  • Baxendale IR; Department of Chemistry, Durham University, South Road, Durham, United Kingdom.
  • Pellicciari R; TES Pharma, Via Palmiro Togliatti 20, 06073, Taverne di Corciano, Perugia, Italy.
  • Macchiarulo A; Laboratory of Medicinal and Advanced Synthetic Chemistry, Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, 06122, Perugia, Italy.
  • Gioiello A; Laboratory of Medicinal and Advanced Synthetic Chemistry, Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, 06122, Perugia, Italy. Electronic address: antimo.gioiello@unipg.it.
Eur J Med Chem ; 242: 114652, 2022 Nov 15.
Article em En | MEDLINE | ID: mdl-36049273
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sódio / Ácidos e Sais Biliares Tipo de estudo: Guideline Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sódio / Ácidos e Sais Biliares Tipo de estudo: Guideline Idioma: En Ano de publicação: 2022 Tipo de documento: Article