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Characterization of serotonin as a candidate biomarker of severity and prognosis of COVID-19 using LC/MS analysis.
Saito, Kosuke; Ishikawa, Rika; Kitamura, Isao; Ogawa, Kumiko; Arakawa, Noriaki; Sun, Yuchen; Imai, Kazuo; Maeda, Takuya; Saito, Yoshiro; Hasegawa, Chihiro.
Afiliação
  • Saito K; Division of Medical Safety Science, National Institute of Health Sciences, Kanagawa, Japan.
  • Ishikawa R; Division of Medical Safety Science, National Institute of Health Sciences, Kanagawa, Japan.
  • Kitamura I; Department of Clinical Laboratory, Nagoya City University East Medical Centre, Nagoya, Japan.
  • Ogawa K; Division of Pathology, National Institute of Health Sciences, Kanagawa, Japan.
  • Arakawa N; Division of Medical Safety Science, National Institute of Health Sciences, Kanagawa, Japan.
  • Sun Y; Division of Medical Safety Science, National Institute of Health Sciences, Kanagawa, Japan.
  • Imai K; Department of Internal Medicine, Self-Defense Forces Central Hospital, Tokyo, Japan; Department of Infectious Disease and Infection Control, Saitama Medical University, Saitama, Japan.
  • Maeda T; Department of Infectious Disease and Infection Control, Saitama Medical University, Saitama, Japan.
  • Saito Y; Division of Medical Safety Science, National Institute of Health Sciences, Kanagawa, Japan. Electronic address: yoshiro@nihs.go.jp.
  • Hasegawa C; Department of Infectious Diseases, Nagoya City University East Medical Centre, Nagoya, Japan.
J Pharmacol Sci ; 150(2): 49-55, 2022 Oct.
Article em En | MEDLINE | ID: mdl-36055751
ABSTRACT
The coronavirus disease 2019 (COVID-19) pandemic has been associated with high mortality worldwide. Owing to its complicated pathophysiology, diagnostic and prognostic biomarkers for effective patient management remain scarce. We analyzed kynurenine, tryptophan, and serotonin levels in the serum of patients with COVID-19 via liquid chromatography/mass spectrometry analysis. Serum serotonin levels were decreased in patients with more severe COVID-19, along with increased kynurenine and decreased tryptophan concentrations. Patients with moderate disease who subsequently worsened showed significantly lower serotonin concentrations compared with those who did not experience severe disease. Serum serotonin levels may represent a valuable biomarker for COVID-19 severity and prognosis.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: COVID-19 / Cinurenina Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: COVID-19 / Cinurenina Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article