Absorption, metabolism and excretion of [<sup>14</sup>C]-sotorasib in healthy male subjects: characterization of metabolites and a minor albumin-sotorasib conjugate.

Vuu, Irene; Dahal, Upendra P; Wang, Zhe; Shen, Xiaomeng; Rodgers, John; Wahlstrom, Jan; Houk, Brett

Absorption, metabolism and excretion of [¹⁴C]-sotorasib in healthy male subjects: characterization of metabolites and a minor albumin-sotorasib conjugate.

Vuu, Irene; Dahal, Upendra P; Wang, Zhe; Shen, Xiaomeng; Rodgers, John; Wahlstrom, Jan; Houk, Brett.

Afiliação

Vuu I; Clinical Pharmacology Modeling and Simulation, Amgen, Inc., Thousand Oaks, CA, USA. ivuu@amgen.com.
Dahal UP; Pharmacokinetics and Drug Metabolism, Amgen, Inc., San Francisco, CA, USA.
Wang Z; Pharmacokinetics and Drug Metabolism, Amgen, Inc., San Francisco, CA, USA.
Shen X; Pharmacokinetics and Drug Metabolism, Amgen, Inc., San Francisco, CA, USA.
Rodgers J; Pharmacokinetics and Drug Metabolism, Amgen, Inc., San Francisco, CA, USA.
Wahlstrom J; Pharmacokinetics and Drug Metabolism, Amgen, Inc., San Francisco, CA, USA.
Houk B; Clinical Pharmacology Modeling and Simulation, Amgen, Inc., Thousand Oaks, CA, USA.

Cancer Chemother Pharmacol ; 90(4): 357-367, 2022 10.

Article em En | MEDLINE | ID: mdl-36063185

Assuntos

Albuminas; Piridinas; Administração Oral; Radioisótopos de Carbono; Fezes; Glutationa; Humanos; Masculino; Piperazinas; Piridinas/farmacocinética; Pirimidinas

Palavras-chave

Mass balance; Metabolites; Oncology; Pharmacokinetics; Sotorasib

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridinas / Albuminas Limite: Humans / Male Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo

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XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridinas / Albuminas Limite: Humans / Male Idioma: En Ano de publicação: 2022 Tipo de documento: Article