VSIG4-expressing tumor-associated macrophages impair anti-tumor immunity.
Biochem Biophys Res Commun
; 628: 18-24, 2022 11 05.
Article
em En
| MEDLINE
| ID: mdl-36063598
ABSTRACT
VSIG4, a newly identified co-inhibitory molecule belonging to the B7-related family, is exclusively expressed on tissue-resident macrophages and is involved in the suppression of T cell proliferation and cytokine production. We sought to characterize the role of VSIG4 in anti-tumor immunity in the tumor microenvironment, focusing on VSIG4-expressing tumor-associated macrophages (TAMs). We found that VSIG4-expressing TAMs negatively regulated antigen-specific T cell proliferation and cytokine production through direct inhibition via cell cycle arrest, but not apoptosis, as well as through their arginase 1 activity. Furthermore, VSIG4-expressing TAMs suppress tumor-specific CD8+ T cell cytotoxicity. Therefore, our results suggest that VSIG4-expressing TAMs could be a negative cellular regulator of anti-tumor immunity in the tumor microenvironment.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Receptores de Complemento
/
Microambiente Tumoral
/
Macrófagos Associados a Tumor
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article