VR-10 polypeptide interacts with CD36 to induce cell apoptosis and autophagy in choroid-retinal endothelial cells: Identification of VR-10 as putative novel therapeutic agent for choroid neovascularization (CNV) treatment.

Tian, Run; Deng, Aiping; Pang, Xiaocong; Chen, Yunli; Gao, Yufei; Liu, Hai; Hu, Zhulin

Tian, Run; Deng, Aiping; Pang, Xiaocong; Chen, Yunli; Gao, Yufei; Liu, Hai; Hu, Zhulin.

Afiliação

Tian R; Department of Ophthalmology, The Affiliated Hospital of Yunnan University, Qingnian Road No. 176, Kunming, Yunnan, China. Electronic address: molly67@ynu.edu.cn.
Deng A; Department of Ophthalmology, The Affiliated Hospital of Yunnan University, Qingnian Road No. 176, Kunming, Yunnan, China. Electronic address: 418548335@qq.com.
Pang X; Institute of Clinical Pharmacology, Peking University, Xueyuan Street No. 38, Haidian District, Beijing, China. Electronic address: xiaocong.pang@pkufh.com.
Chen Y; Department of Ophthalmology, Lijiang People's Hospital, Fuhui Road No. 526, Gucheng District, Lijiang, Yunnan, China. Electronic address: 13988845799@163.com.
Gao Y; Department of Ophthalmology, The Affiliated Hospital of Yunnan University, Qingnian Road No. 176, Kunming, Yunnan, China. Electronic address: gyfyufei@163.com.
Liu H; Department of Ophthalmology, The Affiliated Hospital of Yunnan University, Qingnian Road No. 176, Kunming, Yunnan, China. Electronic address: herry_st@sina.com.
Hu Z; Department of Ophthalmology, The Affiliated Hospital of Yunnan University, Qingnian Road No. 176, Kunming, Yunnan, China. Electronic address: molly7967@163.com.

Peptides ; 157: 170868, 2022 11.

Article em En | MEDLINE | ID: mdl-36067926

Assuntos

Neovascularização de Coroide; Animais; Apoptose; Autofagia; Antígenos CD36; Caspase 3/metabolismo; Caspase 3/farmacologia; Corioide/metabolismo; Corioide/patologia; Neovascularização de Coroide/tratamento farmacológico; Neovascularização de Coroide/genética; Neovascularização de Coroide/metabolismo; Ciclina D1/metabolismo; Ciclina D1/farmacologia; Ciclina D2/metabolismo; Ciclina D2/farmacologia; Modelos Animais de Doenças; Células Endoteliais; Interleucina-17/metabolismo; Interleucina-17/farmacologia; Peptídeos/farmacologia; Proteínas Proto-Oncogênicas c-bcl-2/metabolismo; Proteínas Proto-Oncogênicas c-bcl-2/farmacologia; Ratos; Trombospondina 1/genética; Trombospondina 1/metabolismo; Trombospondina 1/farmacologia; Fator A de Crescimento do Endotélio Vascular/metabolismo; Proteína X Associada a bcl-2/metabolismo

Palavras-chave

Angiogenesis; Choroid neovascularization; Choroid-retinal endothelial cells; Thrombospondin-1; VR-10

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neovascularização de Coroide Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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