Stem cell therapy as a promising strategy in necrotizing enterocolitis.
Mol Med
; 28(1): 107, 2022 09 06.
Article
em En
| MEDLINE
| ID: mdl-36068527
ABSTRACT
Necrotizing enterocolitis (NEC) is a devastating gastrointestinal disease that affects newborns, particularly preterm infants, and is associated with high morbidity and mortality. No effective therapeutic strategies to decrease the incidence and severity of NEC have been developed to date. Stem cell therapy has been explored and even applied in various diseases, including gastrointestinal disorders. Animal studies on stem cell therapy have made great progress, and the anti-inflammatory, anti-apoptotic, and intestinal barrier enhancing effects of stem cells may be protective against NEC clinically. In this review, we discuss the therapeutic mechanisms through which stem cells may function in the treatment of NEC.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Enterocolite Necrosante
Limite:
Animals
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Humans
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Newborn
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article