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Hepatitis-associated Aplastic Anemia.
Gonnot, Maxime; Neumann, Florent; Huet, Frédéric; Maudinas, Raphaëlle; Leblanc, Thierry; Lacaille, Florence.
Afiliação
  • Gonnot M; From the Pediatric Department, Hôpital Universitaire Dijon, France.
  • Neumann F; the Department of Pediatric Hematology, Hôpital Universitaire Dijon, France.
  • Huet F; From the Pediatric Department, Hôpital Universitaire Dijon, France.
  • Maudinas R; From the Pediatric Department, Hôpital Universitaire Dijon, France.
  • Leblanc T; the Department of Pediatric Hematology and Immunology, Hôpital Robert Debré, Assistance Publique - Hôpitaux de Paris (AP-HP), Paris, France.
  • Lacaille F; the Department of Pediatric Gastroenterology-Hepatology-Nutrition, Hôpital Universitaire Necker-Enfants Malades, Assistance Publique - Hôpitaux de Paris (AP-HP), Paris, France.
J Pediatr Gastroenterol Nutr ; 75(5): 553-555, 2022 11 01.
Article em En | MEDLINE | ID: mdl-36070526
Hepatitis-associated aplastic anemia (HAAA) accounts for 4% of autoimmune hepatitis in children. An episode of seronegative autoimmune hepatitis is followed a few days or months later by aplastic anemia or full aplasia. This autoimmune disease could be due to a regulation defect in the immune response to a viral trigger, in a genetically predisposed individual. Other causes of hepatitis or aplastic anemia have to be ruled out. Steroids and azathioprine usually control the liver damage but do not prevent the development of aplastic anemia. Aplastic anemia is treated with either hematopoietic stem cell transplantation in patients with a sibling donor or anti-thymocyte globulins and cyclosporine. We propose guidelines to explore and treat this rare disease. We emphasize on the necessary close collaboration between hepatologists and hematologists.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transplante de Células-Tronco Hematopoéticas / Hepatite Autoimune / Anemia Aplástica Tipo de estudo: Risk_factors_studies Limite: Child / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transplante de Células-Tronco Hematopoéticas / Hepatite Autoimune / Anemia Aplástica Tipo de estudo: Risk_factors_studies Limite: Child / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article