Nonacidic thiophene-based derivatives as potential analgesic and design, synthesis, biological evaluation, and metabolic stability study.

Mikhail, Demiana S; El-Nassan, Hala B; Mahmoud, Sally T; Fahim, Samar H

Mikhail, Demiana S; El-Nassan, Hala B; Mahmoud, Sally T; Fahim, Samar H.

Afiliação

Mikhail DS; Department, of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
El-Nassan HB; Department, of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Mahmoud ST; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Fahim SH; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

Drug Dev Res ; 83(8): 1739-1757, 2022 12.

Article em En | MEDLINE | ID: mdl-36074734

Assuntos

Analgésicos; Tiofenos; Animais; Humanos; Ratos; Analgésicos/farmacologia; Anti-Inflamatórios/farmacologia; Anti-Inflamatórios não Esteroides/farmacologia; Celecoxib/uso terapêutico; Cromatografia Líquida; Ciclo-Oxigenase 2/metabolismo; Inibidores de Ciclo-Oxigenase 2/farmacologia; Edema/tratamento farmacológico; Indometacina/farmacologia; Espectrometria de Massas em Tandem; Tiofenos/farmacologia

Palavras-chave

anti-inflammatory activity; metabolic stability; thiophene

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tiofenos / Analgésicos Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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