Utility of the Ratio between Lactate Dehydrogenase (LDH) Activity and Total Nucleated Cell Counts in Effusions (LDH/TNCC Ratio) for the Diagnosis of Feline Infectious Peritonitis (FIP).
Animals (Basel)
; 12(17)2022 Aug 31.
Article
em En
| MEDLINE
| ID: mdl-36077981
ABSTRACT
BACKGROUND:
We tested the hypothesis that the ratio between lactate dehydrogenase activity (LDH) and total nucleated cell counts (TNCC) in effusions may be useful to diagnose feline infectious peritonitis (FIP).METHODS:
LDH/TNCC ratio was retrospectively evaluated in 648 effusions grouped based on cytology and physicochemical analysis (step 1), on the probability of FIP estimated by additional tests on fluids (step 2) or on other biological samples (step 3, n = 471). Results of different steps were statistically compared. Receiver Operating Characteristic (ROC) curves were designed to assess whether the ratio identify the samples with FIP "probable/almost confirmed". The cut-offs with the highest positive likelihood ratio (LR+) or Youden Index (YI) or with equal sensitivity and specificity were determined.RESULTS:
A high median LDH/TNCC ratio was found in FIP effusions (step1 2.01) and with probable or almost confirmed FIP (step 2 1.99; 2.20 respectively; step 3 1.26; 2.30 respectively). The optimal cut-offs were 7.54 (LR+ 6.58), 0.62 (IY 0.67, sensitivity 89.1%; specificity 77.7%), 0.72 (sensitivity and specificity 79.2%) in step 2 and 2.27 (LR+ 10.39), 0.62 (IY 0.65, sensitivity 82.1%; specificity 83.0%), 0.54 (sensitivity 82.1%; specificity 81.9%) in step 3.CONCLUSIONS:
a high LDH/TNCC ratio support a FIP diagnosis.
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Base de dados:
MEDLINE
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article