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DOSE-RATE EFFECT OF RADIATION ON RAT MAMMARY CARCINOGENESIS AND AN EMERGING ROLE FOR STEM CELL BIOLOGY.
Imaoka, Tatsuhiko; Nishimura, Mayumi; Daino, Kazuhiro; Hosoki, Ayaka; Kudo, Ken-Ichi; Iizuka, Daisuke; Nagata, Kento; Takabatake, Masaru; Nishimura, Yukiko; Kokubo, Toshiaki; Morioka, Takamitsu; Doi, Kazutaka; Shimada, Yoshiya; Kakinuma, Shizuko.
Afiliação
  • Imaoka T; Department of Radiation Effects Research, National Institute of Radiological Sciences, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan.
  • Nishimura M; Department of Radiation Effects Research, National Institute of Radiological Sciences, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan.
  • Daino K; Department of Radiation Effects Research, National Institute of Radiological Sciences, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan.
  • Hosoki A; Department of Radiation Effects Research, National Institute of Radiological Sciences, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan.
  • Kudo KI; Department of Radiation Effects Research, National Institute of Radiological Sciences, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan.
  • Iizuka D; Department of Radiation Life Sciences, School of Medicine, Fukushima Medical University, Fukushima 960-1247, Japan.
  • Nagata K; Department of Radiation Effects Research, National Institute of Radiological Sciences, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan.
  • Takabatake M; Department of Radiation Effects Research, National Institute of Radiological Sciences, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan.
  • Nishimura Y; Department of Radiation Effects Research, National Institute of Radiological Sciences, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan.
  • Kokubo T; Department of Radiological Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo 116-8551, Japan.
  • Morioka T; Department of Radiation Effects Research, National Institute of Radiological Sciences, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan.
  • Doi K; Laboratory Animal and Genome Sciences Section, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan.
  • Shimada Y; Department of Radiation Effects Research, National Institute of Radiological Sciences, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan.
  • Kakinuma S; Department of Radiation Regulatory Science Research, National Institute of Radiological Sciences, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan.
Radiat Prot Dosimetry ; 198(13-15): 1036-1046, 2022 Sep 09.
Article em En | MEDLINE | ID: mdl-36083756
ABSTRACT
The uncertain cancer risk of protracted radiation exposure at low dose rates is an important issue in radiological protection. Tissue stem/progenitor cells are a supposed origin of cancer and may contribute to the dose-rate effect on carcinogenesis. The authors have shown that female rats subjected to continuous whole body γ irradiation as juveniles or young adults have a notably reduced incidence of mammary cancer as compared with those irradiated acutely. Experiments using the mammosphere formation assay suggested the presence of radioresistant progenitor cells. Cell sorting indicated that basal progenitor cells in rat mammary gland were more resistant than luminal progenitors to killing by acute radiation, especially at high doses. Thus, the evidence indicates a cell-type-dependent inactivation of mammary cells that manifests only at high acute doses, implying a link to the observed dose-rate effect on carcinogenesis.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteção Radiológica / Exposição à Radiação Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteção Radiológica / Exposição à Radiação Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article