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Deceased donor kidneys are discarded at higher rates when labeled as high kidney donor profile index.
Crannell, William Christian; Perkins, James D; Leca, Nicolae; Kling, Catherine E.
Afiliação
  • Crannell WC; Division of Transplant Surgery, Department of Surgery, University of Washington, Seattle, Washington, USA.
  • Perkins JD; Division of Transplant Surgery, Department of Surgery, University of Washington, Seattle, Washington, USA.
  • Leca N; Clinical and Bio-Analytics Transplant Laboratory (CBATL), University of Washington, Seattle, Washington, USA.
  • Kling CE; Division of Nephrology, Department of Medicine, University of Washington, Seattle, Washington, USA.
Am J Transplant ; 22(12): 3087-3092, 2022 12.
Article em En | MEDLINE | ID: mdl-36088649
ABSTRACT
The kidney donor risk index (KDRI) and percentile conversion, kidney donor profile index (KDPI), provide a continuous measure of donor quality. Kidneys with a KDPI >85% (KDPI85 ) are referred to as "high KDPI." The KDPI85 cutoff changes every year, impacting which kidneys are labeled as KDPIHIGH . We examine kidney utilization around the KDPI85 cutoff and explore the "high KDPI" labeling effect. KDRI to KDPI Mapping Tables from 2012 to 2020 were used to determine the yearly KDRI85 value. Organ Procurement and Transplantation Network data was used to calculate discard rates and model organ use. KDRI85 varied between 1.768 and 1.888. In a multivariable analysis, kidney utilization was lower for KDPI 86% compared with KDPI 85% kidneys (p = .046). Kidneys with a KDRI between 1.785-1.849 were classified as KDPIHIGH in the years 2015-2017 and KDPILOW in the years 2018-2020. The discard rate was 44.9% when labeled as KDPIHIGH and 39.1% when labeled as KDPILOW (p < .01). For kidneys with the same KDRI, the high KDPI label is associated with increased discard. We should reconsider the appropriateness of the "high KDPI" label.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Obtenção de Tecidos e Órgãos / Transplante de Rim Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Obtenção de Tecidos e Órgãos / Transplante de Rim Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article