Alpha-Synuclein RT-QuIC in Idiopathic Normal Pressure Hydrocephalus.
Ann Neurol
; 92(6): 985-991, 2022 12.
Article
em En
| MEDLINE
| ID: mdl-36094107
ABSTRACT
This study quantified the occurrence of an underlying synucleinopathy in 50 patients with idiopathic normal pressure hydrocephalus by means of real-time quaking-induced conversion, a highly sensitive and specific technique capable of detecting and amplifying misfolded aggregated forms of α-synuclein in the cerebrospinal fluid. Seven patients were positive and they did not differ from negative cases, except for a more frequent L-dopa responsiveness and gait characterized by a wider base. The two groups did not differ in terms of response rate to tap test or shunt surgery, although step length and gait velocity improved by a lesser extent in positive cases. ANN NEUROL 2022;92985-991.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sinucleinopatias
/
Hidrocefalia de Pressão Normal
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article