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No evidence of brown adipose tissue activation after 24 weeks of supervised exercise training in young sedentary adults in the ACTIBATE randomized controlled trial.
Martinez-Tellez, Borja; Sanchez-Delgado, Guillermo; Acosta, Francisco M; Alcantara, Juan M A; Amaro-Gahete, Francisco J; Martinez-Avila, Wendy D; Merchan-Ramirez, Elisa; Muñoz-Hernandez, Victoria; Osuna-Prieto, Francisco J; Jurado-Fasoli, Lucas; Xu, Huiwen; Ortiz-Alvarez, Lourdes; Arias-Tellez, María J; Mendez-Gutierrez, Andrea; Labayen, Idoia; Ortega, Francisco B; Schönke, Milena; Rensen, Patrick C N; Aguilera, Concepción M; Llamas-Elvira, José M; Gil, Ángel; Ruiz, Jonatan R.
Afiliação
  • Martinez-Tellez B; PROFITH (PROmoting FITness and Health through Physical Activity) Research Group, Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Granada, Spain.
  • Sanchez-Delgado G; Department of Medicine, Division of Endocrinology and Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands.
  • Acosta FM; Department of Education, Faculty of Education Sciences and SPORT Research Group (CTS-1024), CERNEP Research Center, University of Almería, Almería, Spain.
  • Alcantara JMA; PROFITH (PROmoting FITness and Health through Physical Activity) Research Group, Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Granada, Spain.
  • Amaro-Gahete FJ; Pennington Biomedical Research Center, Baton Rouge, LA, USA.
  • Martinez-Avila WD; PROFITH (PROmoting FITness and Health through Physical Activity) Research Group, Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Granada, Spain.
  • Merchan-Ramirez E; Turku PET Centre, University of Turku, Turku, Finland.
  • Muñoz-Hernandez V; Turku PET Centre, Turku University Hospital, Turku, Finland.
  • Osuna-Prieto FJ; InFLAMES Research Flagship Center, University of Turku, Turku, Finland.
  • Jurado-Fasoli L; PROFITH (PROmoting FITness and Health through Physical Activity) Research Group, Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Granada, Spain.
  • Xu H; PROFITH (PROmoting FITness and Health through Physical Activity) Research Group, Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Granada, Spain.
  • Ortiz-Alvarez L; EFFECTS-262 Research Group, Department of Physiology, School of Medicine, University of Granada, Granada, Spain.
  • Arias-Tellez MJ; PROFITH (PROmoting FITness and Health through Physical Activity) Research Group, Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Granada, Spain.
  • Mendez-Gutierrez A; PROFITH (PROmoting FITness and Health through Physical Activity) Research Group, Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Granada, Spain.
  • Labayen I; PROFITH (PROmoting FITness and Health through Physical Activity) Research Group, Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Granada, Spain.
  • Ortega FB; PROFITH (PROmoting FITness and Health through Physical Activity) Research Group, Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Granada, Spain.
  • Schönke M; Department of Analytical Chemistry, University of Granada, Granada, Spain.
  • Rensen PCN; Research and Development of Functional Food Center (CIDAF), Granada, Spain.
  • Aguilera CM; PROFITH (PROmoting FITness and Health through Physical Activity) Research Group, Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Granada, Spain.
  • Llamas-Elvira JM; PROFITH (PROmoting FITness and Health through Physical Activity) Research Group, Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Granada, Spain.
  • Gil Á; Department of Biochemistry and Molecular Biology II, "José Mataix Verdú" Institute of Nutrition and Food Technology (INYTA), Biomedical Research Center (CIBM), University of Granada, Granada, Spain.
  • Ruiz JR; PROFITH (PROmoting FITness and Health through Physical Activity) Research Group, Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Granada, Spain.
Nat Commun ; 13(1): 5259, 2022 09 12.
Article em En | MEDLINE | ID: mdl-36097264
Exercise modulates both brown adipose tissue (BAT) metabolism and white adipose tissue (WAT) browning in murine models. Whether this is true in humans, however, has remained unknown. An unblinded randomized controlled trial (ClinicalTrials.gov ID: NCT02365129) was therefore conducted to study the effects of a 24-week supervised exercise intervention, combining endurance and resistance training, on BAT volume and activity (primary outcome). The study was carried out in the Sport and Health University Research Institute and the Virgen de las Nieves University Hospital of the University of Granada (Spain). One hundred and forty-five young sedentary adults were assigned to either (i) a control group (no exercise, n = 54), (ii) a moderate intensity exercise group (MOD-EX, n = 48), or (iii) a vigorous intensity exercise group (VIG-EX n = 43) by unrestricted randomization. No relevant adverse events were recorded. 97 participants (34 men, 63 women) were included in the final analysis (Control; n = 35, MOD-EX; n = 31, and VIG-EX; n = 31). We observed no changes in BAT volume (Δ Control: -22.2 ± 52.6 ml; Δ MOD-EX: -15.5 ± 62.1 ml, Δ VIG-EX: -6.8 ± 66.4 ml; P = 0.771) or 18F-fluorodeoxyglucose uptake (SUVpeak Δ Control: -2.6 ± 3.1 ml; Δ MOD-EX: -1.2 ± 4.8, Δ VIG-EX: -2.2 ± 5.1; p = 0.476) in either the control or the exercise groups. Thus, we did not find any evidence of an exercise-induced change on BAT volume or activity in young sedentary adults.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tecido Adiposo Marrom / Fluordesoxiglucose F18 Tipo de estudo: Clinical_trials Limite: Adult / Animals / Female / Humans / Male País como assunto: Europa Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tecido Adiposo Marrom / Fluordesoxiglucose F18 Tipo de estudo: Clinical_trials Limite: Adult / Animals / Female / Humans / Male País como assunto: Europa Idioma: En Ano de publicação: 2022 Tipo de documento: Article