Significant inverse association of testosterone level with penile deformity severity in Japanese males with Peyronie's disease.
Int J Urol
; 30(1): 36-42, 2023 01.
Article
em En
| MEDLINE
| ID: mdl-36103039
ABSTRACT
OBJECTIVES:
We evaluated the relationship between penile curvature and testosterone in Peyronie's disease patients treated in Japan.METHODS:
Data were obtained from 109 patients with Peyronie's disease treated with surgery at our hospital between April 2004 and December 2019. Penile deformity assessment was based on findings of a rigid erection induced by intracavernosal injection. Low total testosterone level was defined as <300 ng/dl. Patients were divided into two groups according to curvature severity (I, <60°; II ≥60°), then clinical factors including total testosterone were compared. Uni- and multivariate logistic regression analyses were performed to identify factors predicting severe penile deformity (≥60°).RESULTS:
For all patients, mean total testosterone was 469 ng/dl and median curvature was 50°, with a significant inverse correlation found between curvature and testosterone level (p < 0.0001). Group I and II patients numbered 55 and 54, respectively. Mean total testosterone for Group II was 397 ng/dl, significantly lower than Group I (539 ng/dl). Median curvature in 15 patients with a low testosterone level was 80°, significantly higher than those with a normal testosterone range (50°). Univariable and multivariable logistic regression analysis indicated total testosterone, follicle stimulating hormone, and C-reactive protein as significant factors correlated with severe penile deformity, among which total testosterone was most relevant.CONCLUSION:
The present findings confirmed that penile deformity severity is correlated with testosterone level in Japanese males with Peyronie's disease.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Induração Peniana
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
/
Male
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article