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Discovery of Highly Potent Daphnane Diterpenoids Uncovers Importin-ß1 as a Druggable Vulnerability in Castration-Resistant Prostate Cancer.
Huang, Jia-Luo; Yan, Xue-Long; Li, Wei; Fan, Run-Zhu; Li, Shen; Chen, Jianghe; Zhang, Zhenhua; Sang, Jun; Gan, Lu; Tang, Gui-Hua; Chen, Hongwu; Wang, Junjian; Yin, Sheng.
Afiliação
  • Huang JL; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, P.R. China.
  • Yan XL; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, P.R. China.
  • Li W; School of Pharmacy, Guizhou Medical University, Guian New District, Guizhou 550025, P.R. China.
  • Fan RZ; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, P.R. China.
  • Li S; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, P.R. China.
  • Chen J; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, P.R. China.
  • Zhang Z; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, P.R. China.
  • Sang J; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, P.R. China.
  • Gan L; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, P.R. China.
  • Tang GH; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, P.R. China.
  • Chen H; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, P.R. China.
  • Wang J; Department of Biochemistry and Molecular Medicine, School of Medicine, University of California Davis, Sacramento, California 95817, United States.
  • Yin S; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, P.R. China.
J Am Chem Soc ; 144(38): 17522-17532, 2022 09 28.
Article em En | MEDLINE | ID: mdl-36103720
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Diterpenos / Neoplasias de Próstata Resistentes à Castração Tipo de estudo: Prognostic_studies Limite: Humans / Male Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Diterpenos / Neoplasias de Próstata Resistentes à Castração Tipo de estudo: Prognostic_studies Limite: Humans / Male Idioma: En Ano de publicação: 2022 Tipo de documento: Article