Glucocorticoid regulation of lactate release from spinal astrocytes contributes to the induction of spinal LTP of C-fiber-evoked field potentials and the development of mechanical allodynia.

Huang, Ruizhen; Han, Shuang; Qiu, Yuxin; Zhou, Taihe; Wu, Yuning; Du, Hongchun; Xu, Jing; Wei, Xuhong

Huang, Ruizhen; Han, Shuang; Qiu, Yuxin; Zhou, Taihe; Wu, Yuning; Du, Hongchun; Xu, Jing; Wei, Xuhong.

Afiliação

Huang R; Department of Physiology and Pain Research Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China.
Han S; Department of Physiology and Pain Research Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China.
Qiu Y; Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.
Zhou T; Department of Physiology and Pain Research Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China.
Wu Y; Department of Physiology and Pain Research Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China.
Du H; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China. Electronic address: duhchun@mail.sysu.edu.cn.
Xu J; Department of Physiology and Pain Research Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China; Center for Laboratory Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, China.
Wei X; Department of Physiology and Pain Research Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China. Electronic address: weixhon

Neuropharmacology ; 219: 109253, 2022 11 15.

Article em En | MEDLINE | ID: mdl-36108796

Assuntos

Hiperalgesia; Potenciação de Longa Duração; Animais; Astrócitos/metabolismo; Glucocorticoides/metabolismo; Glucocorticoides/farmacologia; Hiperalgesia/metabolismo; Ácido Láctico/metabolismo; Potenciação de Longa Duração/fisiologia; Camundongos; Dor/metabolismo; Células do Corno Posterior; Ratos; Ratos Sprague-Dawley; Receptores de Glucocorticoides/metabolismo; Medula Espinal/fisiologia; Corno Dorsal da Medula Espinal

Palavras-chave

Astrocyte; Glucocorticoid; Lactate; Long term potentiation; Mechanical allodynia; Spinal cord

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Potenciação de Longa Duração / Hiperalgesia Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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