Extracellular vesicles derived from bone marrow mesenchymal stem cells loaded on magnetic nanoparticles delay the progression of diabetic osteoporosis via delivery of miR-150-5p.

Xu, Chen; Wang, Zhaodong; Liu, Yajun; Wei, Bangguo; Liu, Xiangyu; Duan, Keyou; Zhou, Pinghui; Xie, Zhao; Wu, Min; Guan, Jianzhong

Xu, Chen; Wang, Zhaodong; Liu, Yajun; Wei, Bangguo; Liu, Xiangyu; Duan, Keyou; Zhou, Pinghui; Xie, Zhao; Wu, Min; Guan, Jianzhong.

Afiliação

Xu C; Department of Orthopedics, the First Affiliated Hospital of Bengbu Medical College, No. 287, Changhuai Road, Bengbu, 233000, Anhui Province, People's Republic of China.
Wang Z; Anhui Province Key Laboratory of Tissue Transplantation (Bengbu Medical College), Bengbu, 233000, Anhui Province, People's Republic of China.
Liu Y; Jinan University, Guangzhou, 510000, Guangdong Province, People's Republic of China.
Wei B; Department of Orthopedics, the First Affiliated Hospital of Bengbu Medical College, No. 287, Changhuai Road, Bengbu, 233000, Anhui Province, People's Republic of China.
Liu X; Department of Orthopedics, the First Affiliated Hospital of Bengbu Medical College, No. 287, Changhuai Road, Bengbu, 233000, Anhui Province, People's Republic of China.
Duan K; Department of Orthopedics, the First Affiliated Hospital of Bengbu Medical College, No. 287, Changhuai Road, Bengbu, 233000, Anhui Province, People's Republic of China.
Zhou P; Department of Orthopedics, the First Affiliated Hospital of Bengbu Medical College, No. 287, Changhuai Road, Bengbu, 233000, Anhui Province, People's Republic of China.
Xie Z; Department of Orthopedics, the First Affiliated Hospital of Bengbu Medical College, No. 287, Changhuai Road, Bengbu, 233000, Anhui Province, People's Republic of China.
Wu M; Department of Orthopedics, the First Affiliated Hospital of Bengbu Medical College, No. 287, Changhuai Road, Bengbu, 233000, Anhui Province, People's Republic of China.
Guan J; Anhui Province Key Laboratory of Tissue Transplantation (Bengbu Medical College), Bengbu, 233000, Anhui Province, People's Republic of China.

Cell Biol Toxicol ; 39(4): 1257-1274, 2023 08.

Article em En | MEDLINE | ID: mdl-36112264

Assuntos

Diabetes Mellitus; Vesículas Extracelulares; Nanopartículas de Magnetita; Células-Tronco Mesenquimais; MicroRNAs; Osteoporose; Ratos; Animais; MicroRNAs/metabolismo; beta Catenina/metabolismo; Metaloproteinase 14 da Matriz/metabolismo; Diferenciação Celular/fisiologia; Dióxido de Silício; Ratos Sprague-Dawley; Osteoporose/terapia; Osteoporose/metabolismo; Células-Tronco Mesenquimais/metabolismo; Diabetes Mellitus/metabolismo

Palavras-chave

Bone marrow mesenchymal stem cells; Diabetic osteoporosis; Extracellular vesicles; MMP14; Magnetic nanoparticles; MicroRNA-150-5p; Osteogenesis; Wnt/ß-catenin pathway

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Osteoporose / MicroRNAs / Diabetes Mellitus / Nanopartículas de Magnetita / Células-Tronco Mesenquimais / Vesículas Extracelulares Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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