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Locally transplanted human urine-induced nephron progenitor cells contribute to renal repair in mice kidney with diabetic nephropathy.
Gao, Wei-Wei; Chun, So Young; Kim, Bum Soo; Ha, Yun-Sok; Lee, Jun Nyung; Lee, Eun Hye; Kim, In Yong; You, Seungkwon; Kwon, Tae Gyun.
Afiliação
  • Gao WW; Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, South Korea; Institute of Future Medicine, STEMLAB, Inc., Seoul, 02841, South Korea.
  • Chun SY; BioMedical Research Institute, Kyungpook National University Hospital, Daegu, 41940, South Korea.
  • Kim BS; Department of Urology, School of Medicine, Kyungpook National University, Daegu, 41405, South Korea.
  • Ha YS; Department of Urology, School of Medicine, Kyungpook National University, Daegu, 41405, South Korea.
  • Lee JN; Department of Urology, School of Medicine, Kyungpook National University, Daegu, 41405, South Korea.
  • Lee EH; Joint Institute for Regenerative Medicine, Kyungpook National University, Daegu, 41940, Republic of Korea.
  • Kim IY; Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, South Korea. Electronic address: iykim@korea.ac.kr.
  • You S; Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, South Korea. Electronic address: bioseung@korea.ac.kr.
  • Kwon TG; Department of Urology, School of Medicine, Kyungpook National University, Daegu, 41405, South Korea. Electronic address: tgkwon@knu.ac.kr.
Biochem Biophys Res Commun ; 629: 128-134, 2022 11 12.
Article em En | MEDLINE | ID: mdl-36116375
ABSTRACT
Chronic Kidney Disease (CKD) is increasingly recognized as a global public health issue. Diabetic nephropathy (DN), also known as diabetic kidney disease, is a leading cause of CKD. Regenerative medicine strategy employing nephron progenitor cells (NPCs) is worthy of consideration as an alternative to shortage of donor organs for kidney transplantation. In previous study, we successfully generated induced NPCs (iNPCs) from human urine-derived cells that resembled human embryonic stem cell-derived NPCs. Here, we aimed to investigate the therapeutic potential of iNPCs in DN animal model. The results revealed the therapeutic effect of iNPCs as follows (1) diminished glomerular hypertrophy, (2) reduced tubulointerstitial fibrosis, (3) low blood urea nitrogen, serum creatinine and albuminuria value, (4) decreased inflammation/fibrosis, (5) enhanced renal regeneration and (6) confirmed safety. This study demonstrates that human iNPCs have a therapeutic potential as a cell source for transplantation in patients with kidney diseases.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Diabetes Mellitus / Nefropatias Diabéticas / Insuficiência Renal Crônica Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Diabetes Mellitus / Nefropatias Diabéticas / Insuficiência Renal Crônica Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article