Wireless multi-lateral optofluidic microsystems for real-time programmable optogenetics and photopharmacology.
Nat Commun
; 13(1): 5571, 2022 09 22.
Article
em En
| MEDLINE
| ID: mdl-36137999
ABSTRACT
In vivo optogenetics and photopharmacology are two techniques for controlling neuronal activity that have immense potential in neuroscience research. Their applications in tether-free groups of animals have been limited in part due to tools availability. Here, we present a wireless, battery-free, programable multilateral optofluidic platform with user-selected modalities for optogenetics, pharmacology and photopharmacology. This system features mechanically compliant microfluidic and electronic interconnects, capabilities for dynamic control over the rates of drug delivery and real-time programmability, simultaneously for up to 256 separate devices in a single cage environment. Our behavioral experiments demonstrate control of motor behaviors in grouped mice through in vivo optogenetics with co-located gene delivery and controlled photolysis of caged glutamate. These optofluidic systems may expand the scope of wireless techniques to study neural processing in animal models.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neurociências
/
Optogenética
Limite:
Animals
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article