C-to-U RNA Editing: A Site Directed RNA Editing Tool for Restoration of Genetic Code.
Genes (Basel)
; 13(9)2022 09 12.
Article
em En
| MEDLINE
| ID: mdl-36140804
ABSTRACT
The restoration of genetic code by editing mutated genes is a potential method for the treatment of genetic diseases/disorders. Genetic disorders are caused by the point mutations of thymine (T) to cytidine (C) or guanosine (G) to adenine (A), for which gene editing (editing of mutated genes) is a promising therapeutic technique. In C-to-Uridine (U) RNA editing, it converts the base C-to-U in RNA molecules and leads to nonsynonymous changes when occurring in coding regions; however, for G-to-A mutations, A-to-I editing occurs. Editing of C-to-U is not as physiologically common as that of A-to-I editing. Although hundreds to thousands of coding sites have been found to be C-to-U edited or editable in humans, the biological significance of this phenomenon remains elusive. In this review, we have tried to provide detailed information on physiological and artificial approaches for C-to-U RNA editing.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Timina
/
Edição de RNA
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article