Orofacial Deformities in 3 Related Rhesus Monkeys (Macaca mulatta) Resembling Human Binder's Syndrome.
Cleft Palate Craniofac J
; 61(1): 150-154, 2024 01.
Article
em En
| MEDLINE
| ID: mdl-36147021
ABSTRACT
Binder's syndrome is a rare congenital deformity characterized by midface hypoplasia, particularly around the nasomaxillary area. Genetic etiology or developmental failure caused by prenatal exposure to teratological agents has been considered. In this article, we present 3 related rhesus monkeys born with orofacial deformities similar to those found in infants with the Binder phenotype. For the first time, a primate biomodel for this condition is presented. The clinical description and association with management and environmental factors are discussed. These findings reinforce the knowledge about the relationship between possible vitamin K metabolism interference and Binder's syndrome.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Nariz
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Anormalidades Maxilofaciais
Limite:
Animals
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Female
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Humans
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Infant
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Pregnancy
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article