Development of new Alzheimer's disease drug candidates using donepezil as a key model.

Eissa, Kholoud I; Kamel, Mona M; Mohamed, Lamia W; Kassab, Asmaa E

Eissa, Kholoud I; Kamel, Mona M; Mohamed, Lamia W; Kassab, Asmaa E.

Afiliação

Eissa KI; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Kamel MM; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Mohamed LW; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Kassab AE; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

Arch Pharm (Weinheim) ; 356(1): e2200398, 2023 Jan.

Article em En | MEDLINE | ID: mdl-36149034

Assuntos

Doença de Alzheimer; Humanos; Idoso; Donepezila/farmacologia; Donepezila/química; Doença de Alzheimer/tratamento farmacológico; Inibidores da Colinesterase/farmacologia; Inibidores da Colinesterase/química; Relação Estrutura-Atividade; Acetilcolinesterase/metabolismo; Peptídeos beta-Amiloides

Palavras-chave

Alzheimer's disease; donepezil; hybrid; multitarget

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Alzheimer Tipo de estudo: Prognostic_studies Limite: Aged / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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