Early echocardiographic evaluation of right ventricular load adaptability after sequential combination treatment in pulmonary arterial hypertension.
Herz
; 48(4): 316-324, 2023 Aug.
Article
em En
| MEDLINE
| ID: mdl-36149453
ABSTRACT
BACKGROUND:
Using the tricuspid annular plane systolic excursion (TAPSE)/pulmonary arterial systolic pressure (PASP) ratio as an index of right ventricular load adaptability, we aimed to evaluate early changes in right heart contractile function of patients with group 1 pulmonary artery hypertension (PAH) after sequential combination PAH-specific therapy.METHODS:
A total of 49 patients with group 1 PAH and 31 control participants were included in the study. The baseline clinical and echocardiographic data of the control and PAH group were compared. Subsequently, clinical and echocardiographic data of PAH patients before treatment and at 6 months after PAH-specific treatment were analyzed.RESULTS:
A significant increase in the TAPSE/PASP ratio was found in patients at 6 months of PAH-specific treatment (0.25⯱ 0.14; 0.33⯱ 0.16, pâ¯< 0.001). Right atrial pressure (8â¯mmâ¯Hg [5-10]; 5â¯mmâ¯Hg [3-8], pâ¯< 0.001) and PASP (80.8⯱ 30.6â¯mmâ¯Hg; 65.9⯱ 25.7â¯mmâ¯Hg, pâ¯< 0.001) were significantly lower after sequential combination PAH-specific therapy. Negative correlations were found between the TAPSE/PASP ratio and Nterminal pro-B-type natriuretic peptide (râ¯= -0.524, pâ¯< 0.001), tricuspid regurgitation velocity (râ¯= -0.749, pâ¯< 0.001), right atrial area (râ¯= -0.298, pâ¯= 0.037), and right atrial pressure (râ¯= -0.463, pâ¯= 0.001).CONCLUSION:
In patients with group 1 PAH, echocardiographic evaluation at the early stage of treatment (6 months) shows a significant improvement in the TAPSE/PASP ratio indicating right ventricular load adaptation. Comprehensive studies are needed on the routine use of the TAPSE/PASP ratio in the risk assessment of PAH patients.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Disfunção Ventricular Direita
/
Hipertensão Arterial Pulmonar
/
Hipertensão Pulmonar
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article