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Investigation of atropisomeric transformation of a novel PDE4 inhibitor with tetrahydroisoquinoline-based amide group and its primary study of binding to HSA.
Chen, Huanhuan; Zhu, Tingfei; Sun, Ling; Xiang, Lili; Han, Haiyun; Luo, Xiaomin; Chen, Dongying.
Afiliação
  • Chen H; Laboratory of Pharmaceutical Analysis, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Rd. Zuchongzhi, Zhangjiang Hi-Tech Park, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China.
  • Zhu T; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Rd. Zuchongzhi, Zhangjiang Hi-Tech Park, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China.
  • Sun L; Laboratory of Pharmaceutical Analysis, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Rd. Zuchongzhi, Zhangjiang Hi-Tech Park, Shanghai 201203, China. Electronic address: sunling@simm.ac.cn.
  • Xiang L; Laboratory of Pharmaceutical Analysis, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Rd. Zuchongzhi, Zhangjiang Hi-Tech Park, Shanghai 201203, China. Electronic address: xianglili@simm.ac.cn.
  • Han H; Laboratory of Pharmaceutical Analysis, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Rd. Zuchongzhi, Zhangjiang Hi-Tech Park, Shanghai 201203, China. Electronic address: hyhan@simm.ac.cn.
  • Luo X; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Rd. Zuchongzhi, Zhangjiang Hi-Tech Park, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: xmluo
  • Chen D; Laboratory of Pharmaceutical Analysis, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Rd. Zuchongzhi, Zhangjiang Hi-Tech Park, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: dychen@simm.ac.cn.
J Pharm Biomed Anal ; 221: 115056, 2022 Nov 30.
Article em En | MEDLINE | ID: mdl-36150299
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tetra-Hidroisoquinolinas / Inibidores da Fosfodiesterase 4 Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tetra-Hidroisoquinolinas / Inibidores da Fosfodiesterase 4 Idioma: En Ano de publicação: 2022 Tipo de documento: Article