Research Progress on the Role of Sirtuin 1 in Cerebral Ischemia.
Cell Mol Neurobiol
; 43(5): 1769-1783, 2023 Jul.
Article
em En
| MEDLINE
| ID: mdl-36153473
ABSTRACT
A significant amount of evidence from the past few years has shown that Sirtuin 1 (SIRT1), a histone deacetylase dinucleotide of nicotinamide adenine dinucleotide (NAD+) is closely related to the cerebral ischemia. Several potential neuroprotective strategies like resveratrol, ischemia preconditioning, and caloric restriction exert their neuroprotection effects through SIRT1-related signaling pathway. However, the potential mechanisms and neuroprotection of SIRT1 in the process of cerebral ischemia injury development and recovery have not been systematically elaborated. This review summarized the the deacetylase activity and distribution of SIRT1 as well as analyzed the roles of SIRT1 in astrocytes, microglia, neurons, and brain microvascular endothelial cells (BMECs), and the molecular mechanisms of SIRT1 in cerebral ischemia, providing a theoretical basis for exploration of new therapeutic target in future.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Lesões Encefálicas
/
Isquemia Encefálica
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article