Platelet degranulation and bleeding phenotype in a large cohort of Von Willebrand disease patients.
Br J Haematol
; 197(4): 497-501, 2022 05.
Article
em En
| MEDLINE
| ID: mdl-36165954
ABSTRACT
Von Willebrand disease (VWD) is a bleeding disorder caused by quantitative (type 1 or 3) or qualitative (type 2A/2B/2M/2N) defects of circulating von Willebrand factor (VWF). Circulating VWF levels not always fully explain bleeding phenotypes, suggesting a role for alternative factors, like platelets. Here, we investigated platelet factor 4 (PF4) in a large cohort of patients with VWD. PF4 levels were lower in type 2B and current bleeding phenotype was significantly associated with higher PF4 levels, particularly in type 1 VWD. Based on our findings we speculate that platelet degranulation and cargo release may play a role across VWD subtypes.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doenças de von Willebrand
Tipo de estudo:
Etiology_studies
/
Qualitative_research
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article