The long-term relation between physical activity and executive function in the Rotterdam Study.
Eur J Epidemiol
; 38(1): 71-81, 2023 Jan.
Article
em En
| MEDLINE
| ID: mdl-36166135
ABSTRACT
BACKGROUND:
Research on the association between physical inactivity and cognitive decline and dementia is dominated by studies with short-term follow-up, that might be biased by reverse causality.OBJECTIVE:
Investigate the long-term association between physical activity, cognition, and the rate of age-associated cognitive decline.METHODS:
We investigated the association between late-life physical activity and executive functioning and rate of decline of executive abilities during follow-up of up to 16 years, in 3553 participants of the prospective Rotterdam Study cohort. Measurement took place in 1997-1999, 2002-2004, 2009-2011, and 2014-2015.RESULTS:
At baseline (age ± 72 years), higher levels of physical activity were associated with higher levels of executive functioning (adjusted mean difference = 0.03, 95% CI 0.00 ; 0.06, p = 0.03). This difference remained intact up to 16 years of follow-up. The level of physical activity at baseline was unrelated to the rate of decline of executive abilities over time, in the whole group (adjusted mean difference in changetime*physical activity = 0.00, 95% CI -0.00 ; 0.01, p = 0.31). However, stratification by APOE genotype showed that the accelerated decline of executive abilities observed in those with the ApoE-ε4 allele might be attenuated by higher levels of physical activity in late adulthood (ApoE-ε4 carriers Btime*physical activity = 0.01, 95% CI 0.00 ; 0.01, p = 0.03).CONCLUSION:
Higher levels of physical activity in late adulthood are related to higher levels of executive functioning, up to 16 years of follow-up. Accelerated decline of executive abilities observed in those with the ApoE-ε4 allele might be mitigated by higher levels of physical activity.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Exercício Físico
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Função Executiva
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Disfunção Cognitiva
Limite:
Aged
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Aged80
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Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article