Angiotensin II type-2 receptor activation in alveolar macrophages mediates protection against cigarette smoke-induced chronic obstructive pulmonary disease.

Mei, Dan; Liao, Wupeng; Gan, Phyllis X L; Tran, Quy T N; Chan, Christabel C M Y; Heng, C K Matthew; Wong, W S Fred

Mei, Dan; Liao, Wupeng; Gan, Phyllis X L; Tran, Quy T N; Chan, Christabel C M Y; Heng, C K Matthew; Wong, W S Fred.

Afiliação

Mei D; Department of Pharmacology, Yong Loo Lin School of Medicine, National University Health System, 117600, Singapore. Electronic address: meidan_nh@163.com.
Liao W; Department of Pharmacology, Yong Loo Lin School of Medicine, National University Health System, 117600, Singapore; Singapore-HUJ Alliance for Research and Enterprise, National University of Singapore, 138602, Singapore.
Gan PXL; Department of Pharmacology, Yong Loo Lin School of Medicine, National University Health System, 117600, Singapore.
Tran QTN; Department of Pharmacology, Yong Loo Lin School of Medicine, National University Health System, 117600, Singapore; Singapore-HUJ Alliance for Research and Enterprise, National University of Singapore, 138602, Singapore.
Chan CCMY; Department of Pharmacology, Yong Loo Lin School of Medicine, National University Health System, 117600, Singapore; Drug Discovery & Optimization Platform, Yong Loo Lin School of Medicine, National University Health System, 117600, Singapore.
Heng CKM; Department of Pharmacology, Yong Loo Lin School of Medicine, National University Health System, 117600, Singapore; Singapore-HUJ Alliance for Research and Enterprise, National University of Singapore, 138602, Singapore.
Wong WSF; Department of Pharmacology, Yong Loo Lin School of Medicine, National University Health System, 117600, Singapore; Singapore-HUJ Alliance for Research and Enterprise, National University of Singapore, 138602, Singapore; Drug Discovery & Optimization Platform, Yong Loo Lin School of Medicine, Nat

Pharmacol Res ; 184: 106469, 2022 10.

Article em En | MEDLINE | ID: mdl-36167278

Assuntos

Fumar Cigarros; Doença Pulmonar Obstrutiva Crônica; Angiotensina II/metabolismo; Animais; Fumar Cigarros/efeitos adversos; Imidazóis; Inflamação/metabolismo; Macrófagos Alveolares/metabolismo; Camundongos; Fosfatases da Proteína Quinase Ativada por Mitógeno; NF-kappa B/metabolismo; Doença Pulmonar Obstrutiva Crônica/tratamento farmacológico; Doença Pulmonar Obstrutiva Crônica/etiologia; Receptor Tipo 2 de Angiotensina/metabolismo; Sirtuína 1/metabolismo; Sulfonamidas; Tiofenos; Nicotiana

Palavras-chave

Compound 21; Macrophage phenotyping; Metabolic reprogramming; Phagocytosis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença Pulmonar Obstrutiva Crônica / Fumar Cigarros Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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